118842-87-8Relevant articles and documents
Synthesis of ginkgolic acid analogues and evaluation of their molluscicidal activity
Zhang, Peng,Pan, Jiahu,Duan, Wanxing,Li, Xuedong,Zhang, Yao,Zhou, Yibiao,Jiang, Qingwu,Mao, Zuohua,Yu, Peizhong
, p. 4059 - 4069 (2011/07/07)
Based on the molluscicidal activity of ginkgolic acids (GAs) isolated from Ginkgo biloba L, a series of Z/E isomers of GA analogues were prepared and evaluated for their molluscicidal activities against the host snail Oncomelania hupensis. The results and analysis of the structure-activity relationship revealed that the E-isomers showed better molluscicidal activities than their Z-isomers. Molluscicidal activities decreased with the shortening of the alkenyl chain lengths.
Efficient total synthesis of AI-77-B, a gastroprotective substance from Bacillus pumilus AI-77
Hamada,Hara,Kawai,Kohno,Shioiri
, p. 8635 - 8652 (2007/10/02)
First total synthesis of AI-77-B (1), a gastroprotective substance from Bacillus pumilus AI-77, was achieved in a stereoselective and convergent manner. In this synthesis, the dihydroisocoumarin part 2 was constructed in one step through 1,2-addition of the benzylic anion 17b to Boc-L-leucinal 7b. The hydroxy amino acid 4 was elaborated from (R)-glutamic acid in a highly stereoselective manner. Condensation of 2·HCl and 4, intramolecular Pinner reaction, followed by mild hydrolysis afforded AI-77-B (1).
