1188475-96-8

Basic information

• Product Name: tert-butyl (4-hydroxycyclohexyl)methylcarbamate
• Synonyms: tert-butyl (4-hydroxycyclohexyl)methylcarbamate;4-[(Boc-amino)methyl]cyclohexanol;1-(BOC-AMINOMETHYL)-4-HYDROXYCYCLOHEXANE
• CAS NO: 1188475-96-8
• Molecular Formula: C₁₂H₂₃NO₃
• Molecular Weight: 229.31592
• Mol File: 1188475-96-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: tert-butyl (4-hydroxycyclohexyl)methylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (4-hydroxycyclohexyl)methylcarbamate(1188475-96-8)
• EPA Substance Registry System: tert-butyl (4-hydroxycyclohexyl)methylcarbamate(1188475-96-8)

Safety Data

• Hazardous Substances Data: 1188475-96-8(Hazardous Substances Data)

Usage

General Description

Tert-butyl (4-hydroxycyclohexyl)methylcarbamate, also known as Oxybenzone or benzophenone-3, is a chemical commonly used in sunscreens and other skincare products as a UV filter. It works by absorbing and dissipating UV radiation, helping to protect the skin from sun damage and prevent sunburn. However, there is growing concern about the potential health risks associated with this chemical, as some studies have linked it to hormone disruption and allergic reactions in sensitive individuals. Additionally, oxybenzone has been found to have negative impacts on marine ecosystems, as it can be harmful to coral reefs and other marine organisms. As a result, some countries and regions have banned or restricted the use of oxybenzone in sunscreen products.

Upstream product

• 143323-49-3 (R)-methyl 2-((tert-butoxycarbonyl)amino)-2-(4-hydroxyphenyl)acetate 

Downstream Products

• 1236109-04-8 4-aminomethyl-cyclohexanol trifluoroacetate 

Relevant articles and documents

A multikilogram-scale synthesis of (R)-methyl 2-[(1r,4R)-4-(tert-butoxy- carbonylamino)cyclohexyl]-2-(2-nitrophenylsulfonamido)acetate - A doubly protected building block with three points of variation

A robust and scalable synthesis of (R)-methyl 2-[(1r,4R)-4-(tert- butoxycarbonylamino)cyclohexyl]-2-(2-nitrophenylsulfon-amido)acetate is reported. This serves as a scaffold for the preparation of trans-substituted aminocyclohexanes. The key synthetic step is the reduction of d-4-hydroxyphenylglycine, or a protected equivalent, to achieve the required regiochemistry across the cyclohexyl ring. Georg Thieme Verlag Stuttgart · New York.