1188495-92-2

Upstream product

• 2836-82-0 (o-fluorophenyl)acetone 
• 1072-85-1 o-fluorobromobenzene 
• 15448-47-2 (R)-propylene oxide 

Downstream Products

• 1188411-13-3 2-(4-{[(1S)-2-(2-fluorophenyl)-1-methylethyl]amino}-2-oxo-1,2-dihydropyridin-3-yl)-6-(2-pyrrolidin-1-ylethyl)imidazo[4,5-f]isoindole-5,7(1H,6H)-dione trifluoroacetate 
• 1188412-30-7 (2S)-1-(2-fluorophenyl)propan-2-amine 

Relevant academic research and scientific papers

Straightforward synthesis of enantiopure 2,3-dihydrobenzofurans by a sequential stereoselective biotransformation and chemical intramolecular cyclization

(Equation Presented). A new family of optically active 2,3- dihydrobenzofurans has been prepared by a simple chemoenzymatic asymmetric strategy. This synthetic approach is based on the combination of a lipase-mediated kinetic resolution of 1-aryl-2-propanols or bioreduction of the corresponding ketones followed by an intramolecular cyclization reaction. These novel compounds have been prepared in enantiopure form and in good overall yield through a straightforward route.

NOVEL TYROSINE KINASE INHIBITORS

Provided are compounds of the formula (I): or a stereoisomer, tautomer, salt, hydrate or prodrug thereof that modulate tyrosine kinase activity, compositions comprising the compounds and methods of their use.