118869-05-9Relevant articles and documents
Ethyl acrylate conjugated polystyryl-diphenylphosphine - An extremely efficient catalyst for Henry reaction under solvent-free conditions (SolFC)
Rokhum, Lalthazuala,Bez, Ghanashyam
, p. 300 - 306 (2013)
Over the last few decades, the fast-growing development of polymer supported reagents has led to the synthesis of a variety of reagents on solid support. Some of the major advantages of using such reagents are that they are less hygroscopic, easy to recover, and can be recycled. Here, we have demonstrated that in situ generated ethyl acrylate conjugated polystyryl-diphenylphosphine (PDPP-EA) derived from the reaction of a mixture of polystyryl-diphenylphosphine and ethyl acrylate in a stoichiometric ratio can efficiently catalyze the synthesis of β-nitroalcohols from the reaction of aldehydes and nitroalkanes under solvent-free conditions (SolFC).
Polymer supported DMAP: An easily recyclable organocatalyst for highly atom-economical Henry reaction under solvent-free conditions
Das, Diparjun,Pathak, Gunindra,Rokhum, Lalthazuala
, p. 104154 - 104163 (2016/11/17)
Polymer supported catalysts are regarded as a borderline class of catalysts, which retains the advantages of homogeneous catalysts while securing the ease of recovery by simple filtration and workup of heterogeneous systems. Additionally, such catalysts are less hygroscopic due to the long polymer backbone. Here we have demonstrated that a catalytic amount of polymer supported DMAP (10 mol%) can lead to excellent conversion of an equimolar mixture of aldehyde and nitroalkane exclusively into β-nitroalcohols via the Henry reaction. Unlike most of the commonly used catalysts, polymer supported DMAP can be recovered by simple filtration and reused several times, thereby reducing the operational cost. High synthetic efficiency, total atom economy, near quantitative yields, mild reaction conditions, operational simplicity, easy recovery and reusability of the catalyst, solvent-free reaction conditions and avoidance of traditional reaction workup make the protocol highly significant from Green and Sustainable Chemistry perspectives.
Heterogeneous henry reaction of aldehydes: Diastereoselective synthesis of nitroalcohol derivatives over Mg-Al hydrotalcites
Bulbule, Vivek J.,Deshpande, Vishnu H.,Velu, Subramani,Sudalai, Arumugam,Sivasankar,Sathe
, p. 9325 - 9332 (2007/10/03)
Mg-Al Hydrotalcite (HT) has been found to catalyze the reaction between aldehydes and nitroalkanes very efficiently affording threo nitroalkanols in a highly diastereoselective manner. The ratios of threo/erythro isomers are determined from their respecti
Dichloroisopropoxytitanium Nitronates as Reagents for Stereoselective Henry Reactions
Barrett, Anthony G. M.,Robyr, Chantal,Spilling, Christopher D.
, p. 1233 - 1234 (2007/10/02)
Alkyl nitronates were reacted with aldehydes in the presence of isopropoxytitanium trichloride to give erythro β-nitro alcohols.
