118869-51-5

Basic information

• Product Name: 2-desaminopterin
• Synonyms: 2-desaminopterin
• CAS NO: 118869-51-5
• Molecular Formula: C₁₉H₁₉N₇O₅
• Molecular Weight: 425.39806
• Mol File: 118869-51-5.mol

Chemical Properties

• Boiling Point: 786.9°Cat760mmHg
• Flash Point: 429.7°C
• Appearance: /
• Density: 1.547g/cm³
• Vapor Pressure: 4.34E-26mmHg at 25°C
• Refractive Index: 1.732
• PKA: 3.47±0.10(Predicted)
• CAS DataBase Reference: 2-desaminopterin(CAS DataBase Reference)
• NIST Chemistry Reference: 2-desaminopterin(118869-51-5)
• EPA Substance Registry System: 2-desaminopterin(118869-51-5)

Safety Data

• Hazardous Substances Data: 118869-51-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C19H19N7O5/c20-16-15-17(24-9-23-16)22-8-12(25-15)7-21-11-3-1-10(2-4-11)18(29)26-13(19(30)31)5-6-14(27)28/h1-4,8-9,13,21H,5-7H2,(H,26,29)(H,27,28)(H,30,31)(H2,20,22,23,24)/t13-/m0/s1

Upstream product

• 40127-91-1 2-Amino-5-chloromethylpyrazine-3-carbonitrile 
• 118869-56-0 dimethyl N-<4-<<(2-amino-3-cyanopyrazin-5-yl)methyl>amino>benzoyl>-L-glutamate 
• 52407-60-0 dimethyl N-(4-amino-benzoyl)-L-glutamate 
• 118869-54-8 di-tert-butyl N-<4-<<(4-aminopteridin-6-yl)methyl>amino>benzoyl>-L-glutamate 

Relevant articles and documents

Synthesis and biological activity of the 2-desamino and 2-desamino-2-methyl analogues of aminopterin and methotrexate

The previously undescribed 2-desamino and 2-desamino-2-methyl analogues of aminopterin (AMT) and methotrexate (MTX) were synthesized from 2-amino-5-(chloromethyl)pyrazine-3- carbonitrile. The AMT analogues were obtained via a three-step sequence consistin