118876-58-7

Basic information

• Product Name: NBQX DISODIUM SALT
• Synonyms: NBQX;2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline;FG 9202, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate;FG 9202 hydrate disodium salt, 1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide hydrate disodium salt;NBQX hydrate disodium salt;2,3-Dihydroxy-6-nitrobenzo[f]quinoxaline-7-sulfonamide;6-Nitro-7-sulfamoylbenzo[f]quinoxaline-2,3(1H,4H)-dione;1,2,3,4-Tetrahydro-6-nitro-2,3-dioxo-benzo[f]quinoxaline-7-sulfonamide disodium salt hydrate
• CAS NO: 118876-58-7
• Molecular Formula: C12H8N4O6S
• Molecular Weight: 336.28
• Product Categories: Heterocyclic Compounds;Neurochemicals;Glutamate receptor;Glutamate
• Mol File: 118876-58-7.mol
• Article Data: 0

Chemical Properties

• Melting Point: 361°C
• Boiling Point: 613.386°C at 760 mmHg
• Flash Point: 324.764°C
• Appearance: yellow/solid
• Density: 1.6027 (rough estimate)
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.6000 (estimate)
• Storage Temp.: 0-6°C
• Solubility: methanol: 0.25 mg/mL
• PKA: 7.55±0.20(Predicted)
• Stability: Freezer at -20°C
• CAS DataBase Reference: NBQX DISODIUM SALT(CAS DataBase Reference)
• NIST Chemistry Reference: NBQX DISODIUM SALT(118876-58-7)
• EPA Substance Registry System: NBQX DISODIUM SALT(118876-58-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 118876-58-7(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Crystalline Solid

Uses

Different sources of media describe the Uses of 118876-58-7 differently. You can refer to the following data:
1. A potent and discriminating antagonist for AMPA binding sites. This compound has neuroprotective properties.
2. NBQX disodium salt hydrate has been used:in N-methyl-D-aspartate receptor (NMDAR) kinetic studiesas an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist for the electrophysiological studies cultured neuronsin the extracellular solution for current/voltage (I/V) relationship and rectification index experiments in excitatory postsynaptic currents (EPSCs) mediated by NMDA receptors (EPSCNMDAR)

General Description

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline] is a competitive antagonist, which shows high affinity to 2-amino-3-hydroxy-5-methyl-4-isoxazol propionic acid (AMPA) receptor than kainite receptor.

Biological Activity

Potent, selective and competitive AMPA receptor antagonist. Neuroprotective and anticonvulsant; active in vivo . More water soluble disodium salt of NBQX (2,3-Dioxo-6-nitro-1,2,3,4-tetrahydrobenzo[f]quinoxaline-7-sulfonamide ). Also available as part of the AMPA Receptor Tocriset? .

Biochem/physiol Actions

NBQX [2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline], an anticonvulsant provides protection against white matter damage in spinal cord crush injury and also protects oligodendrocyte in experimental autoimmune encephalomyelitis (EAE). However, its role in preventing inflammation in EAE is not yet clear.

InChI:InChI=1/C12H6N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H2,13,21,22)