1188890-28-9

Basic information

• Product Name: ABT 702 Dihydrochloride
• Synonyms: ABT702 hcl
• CAS NO: 1188890-28-9
• Molecular Formula: C22H21BrCl2N6O
• Molecular Weight: 536.25174
• EINECS: -0
• Mol File: 1188890-28-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility: insoluble in H2O; ≥107.2 mg/mL in DMSO; ≥9.84 mg/mL in EtOH with gentle warming and ultrasonic
• CAS DataBase Reference: ABT 702 Dihydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: ABT 702 Dihydrochloride(1188890-28-9)
• EPA Substance Registry System: ABT 702 Dihydrochloride(1188890-28-9)

Safety Data

• Hazardous Substances Data: 1188890-28-9(Hazardous Substances Data)

Usage

Biological Activity

adenosine (ado) is an endogenous homeostatic inhibitory neuromodulator that reduces cellular excitability at sites of tissue injury and inflammation. inhibition of adenosine kinase (ak), the primary metabolic enzyme for ado, selectively increases ado concentrations at sites of tissue trauma and enhances the analgesic and antiinflammatory actions of ado. abt 702 is a novel, potent nonnucleoside ak inhibitor.

in vitro

abt 702 was active both in inhibiting ak (ic50 ) 1.7 nm) and ado phosphorylation in the intact cells (ic50 ) 50 nm). abt 702 was also highly selective for ak inhibition as compared to other sites of ado action including ada, ado receptors, and ado transport sites [1].

in vivo

abt 702 had dose-dependent antinociceptive and antiinflammatory actions in a variety of animal models of nociceptive, inflammatory, and neuropathic pain. abt 702 is the first of a novel class of potent, selective, non-nucleoside, orally active ak inhibitors that have potent antinociceptive effects in animal models [1].

IC 50

1.7 nm for adenosine kinase

references

[1] lee ch, jiang m, cowart m, gfesser g, perner r, kim kh, gu yg, williams m, jarvis mf, kowaluk ea, stewart ao, bhagwat ss. discovery of 4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin-3-yl)pyrido[2,3-d]pyrimidine, an orally active, non-nucleoside adenosine kinase inhibitor.. j med chem. 2001 jun 21;44(13):2133-8.