Cas 1188917-91-0,N‐(((S)‐3‐(2‐fluoro‐4′‐((((S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐yl)oxy)methyl)‐[1,1′‐biphenyl]‐4‐yl)‐2‐oxooxazolidin‐5‐yl)methyl)acetamide

1188917-91-0

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Product Name: N‐(((S)‐3‐(2‐fluoro‐4′‐((((S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐yl)oxy)methyl)‐[1,1′‐biphenyl]‐4‐yl)‐2‐oxooxazolidin‐5‐yl)methyl)acetamide
Synonyms: N‐(((S)‐3‐(2‐fluoro‐4′‐((((S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐yl)oxy)methyl)‐[1,1′‐biphenyl]‐4‐yl)‐2‐oxooxazolidin‐5‐yl)methyl)acetamide
CAS NO:1188917-91-0
Molecular Formula:
Molecular Weight: 525.493
EINECS: N/A
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Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: N‐(((S)‐3‐(2‐fluoro‐4′‐((((S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐yl)oxy)methyl)‐[1,1′‐biphenyl]‐4‐yl)‐2‐oxooxazolidin‐5‐yl)methyl)acetamide(CAS DataBase Reference)
NIST Chemistry Reference: N‐(((S)‐3‐(2‐fluoro‐4′‐((((S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐yl)oxy)methyl)‐[1,1′‐biphenyl]‐4‐yl)‐2‐oxooxazolidin‐5‐yl)methyl)acetamide(1188917-91-0)
EPA Substance Registry System: N‐(((S)‐3‐(2‐fluoro‐4′‐((((S)‐2‐nitro‐6,7‐dihydro‐5H‐imidazo[2,1‐b][1,3]oxazin‐6‐yl)oxy)methyl)‐[1,1′‐biphenyl]‐4‐yl)‐2‐oxooxazolidin‐5‐yl)methyl)acetamide(1188917-91-0)

Safety Data

Hazard Codes: N/A
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Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1188917-91-0(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1188917-91-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,8,9,1 and 7 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1188917-91:
(9*1)+(8*1)+(7*8)+(6*8)+(5*9)+(4*1)+(3*7)+(2*9)+(1*1)=210
210 % 10 = 0
So 1188917-91-0 is a valid CAS Registry Number.

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1188917-91-0Relevant academic research and scientific papers

Synergistic activity of nitroimidazoleoxazolidinone conjugates against anaerobic bacteria

Cooper, Christopher B.,Denny, William A.,Ding, Charles Z.,Ding, Jun,He, Shijie,Lu, Yu,Lynch, Anthony Simon,Ma, Zhenkun,Upton, Anna M.,Wan, Dawei,Wang, Xiaomei,Yuan, Ying,Zhang, Qian,Zhuang, Zhijun

, (2020/05/29)

The introductions of the bicyclic 4nitroimidazole and the oxazolidinone classes of antimicrobial agents represented the most significant advancements in the infectious disease area during the past two decades. Pretomanid, a bicyclic 4nitroimidazole, and linezolid, an oxazolidinone, are also part of a combination regimen approved recently by the US Food and Drug Administration for the treatment of pulmonary, extensively drug resistant (XDR), treatmentintolerant or nonresponsive multidrugresistant (MDR) Mycobacterium tuberculosis (TB). To identify new antimicrobial agents with reduced propensity for the development of resistance, a series of dualacting nitroimidazoleoxazolidinone conjugates were designed, synthesized and evaluated for their antimicrobial activity. Compounds in this conjugate series have shown synergistic activity against a panel of anaerobic bacteria, including those responsible for serious bacterial infections.

BICYCLIC NITROIMIDAZOLES COVALENTLY LINKED TO SUBSTITUTED PHENYL OXAZOLIDINONES

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Page/Page column 61, (2009/10/22)

The current invention provides a series of bicyclic nitroimidazole- substituted phenyl oxazolidinones in which a bicyclic nitroimidazole pharmacophore is covalently bonded to a phenyl oxazolidinone, their pharmaceutical compositions, and the method of use of the compositions for prevention and treatment of bacterial infections. The bicyclic nitroimidazole-substituted phenyl oxazolidinones possess surprising antibacterial activity against wild- type and resistant strains of pathogens, and are therefore useful for the prevention, control and treatment of a number of human and veterinary bacterial infections caused by these pathogens, such as Mycobacterium tuberculosis.

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