1189124-84-2Relevant academic research and scientific papers
Tunable phosphoramidite ligands for asymmetric hydrovinylation: Ligands par excellence for generation of all-carbon quaternary centers
Smith, Craig R.,Hwan, Jung Lim,Zhang, Aibin,RajanBabu
experimental part, p. 2089 - 2100 (2010/02/28)
α-Alkylstyrenes undergo efficient hydrovinylation (addition of ethene) in the presence of a nickel catalyst prepared from [(allyl)NiBr] 2, Na+[BAr4]- [Ar = 3,5-bis(trifluoromethyl)phenyl], and a phosphoramidite ligand giving products in excellent yields and enantioselectivities. In many cases phosphoramidites derived from achiral 2,2′-biphenol are almost as good as ligands derived from the more expensive enantiopure 1,1′-bi(2-naphthol)s. The hydrovinylation products, which carry two versatile latent functionalities, an aryl and a vinyl group, are potentially useful for the synthesis of several important natural products containing benzylic all-carbon quaternary centers. Georg Thieme Verlag Stuttgart.
