1189147-42-9Relevant articles and documents
Efficient synthesis of 2-substituted pyrido[3,2-d]pyrimidines involving SNAr and palladium-catalyzed cross-coupling reactions
Tikad, Abdellatif,Routier, Sylvain,Akssira, Mohamed,Leger, Jean-Michel,Jarry, Christian,Guillaumet, Gerald
experimental part, p. 2379 - 2384 (2010/02/27)
The efficient and original synthesis of various 2-substituted pyrido[3,2-d]pyrimidines is reported. Starting from 2,4-dichloropyrido [3,2-d]pyrimidine, a regioselective pallado-dehalogenation led to 2-chloropyrido[3,2-d]pyrimidine, which was used in SNAr and palladium-catalyzed cross-coupling reactions in order to afford highly functionalized products in very good yields. Georg Thieme Verlag Stuttgart.