(E)-3-((R)-4-pyrrolidin-2-yl-phenyl)-acrylic acid methyl ester hydrochloride, also known as (R)-PAP, is a chemical compound utilized in the field of medicinal chemistry. It is recognized for its selective and potent agonist activity towards the α7 nicotinic acetylcholine receptor, which is integral to neurological functions and has been linked to several neurological conditions. (R)-PAP is characterized by its capacity to traverse the blood-brain barrier and its favorable safety profile, positioning it as a promising candidate for developing innovative pharmacological interventions for neurological disorders.
1189155-61-0
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Basic information
- Product Name: (E)-3-((R)-4-pyrrolidin-2-yl-phenyl)-acrylic acid methyl ester hydrochloride
- Synonyms: (E)-3-((R)-4-pyrrolidin-2-yl-phenyl)-acrylic acid methyl ester hydrochloride
- CAS NO:1189155-61-0
- Molecular Formula:
- Molecular Weight: 267.755
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: N/A
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: (E)-3-((R)-4-pyrrolidin-2-yl-phenyl)-acrylic acid methyl ester hydrochloride(CAS DataBase Reference)
- NIST Chemistry Reference: (E)-3-((R)-4-pyrrolidin-2-yl-phenyl)-acrylic acid methyl ester hydrochloride(1189155-61-0)
- EPA Substance Registry System: (E)-3-((R)-4-pyrrolidin-2-yl-phenyl)-acrylic acid methyl ester hydrochloride(1189155-61-0)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1189155-61-0(Hazardous Substances Data)
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1189155-61-0 Usage
Uses
Used in Pharmaceutical Industry:(R)-PAP is used as a therapeutic agent for addressing cognitive deficits associated with neurological conditions such as Alzheimer's disease and schizophrenia. Its agonist activity on the α7 nicotinic acetylcholine receptor aids in enhancing cognitive functions and offers potential neuroprotective properties, making it a valuable compound in the development of treatments for these disorders.
Used in Research and Development:
In the field of medical research, (R)-PAP serves as a crucial tool for studying the role of the α7 nicotinic acetylcholine receptor in neurological functions and disorders. Its use in experimental models helps researchers understand the receptor's mechanisms of action and its potential as a target for therapeutic intervention, thereby contributing to the advancement of knowledge in neurology and drug development.
Used in Neuroprotection:
(R)-PAP is utilized as a neuroprotective agent due to its ability to shield neurons from damage and degeneration. Its agonist effect on the α7 nicotinic acetylcholine receptor may contribute to the preservation of neuronal integrity and function, offering potential benefits in conditions where neuroprotection is essential, such as in neurodegenerative diseases or following brain injury.
Check Digit Verification of cas no
The CAS Registry Mumber 1189155-61-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,9,1,5 and 5 respectively; the second part has 2 digits, 6 and 1 respectively.Calculate Digit Verification of CAS Registry Number 1189155-61:
(9*1)+(8*1)+(7*8)+(6*9)+(5*1)+(4*5)+(3*5)+(2*6)+(1*1)=180
180 % 10 = 0
So 1189155-61-0 is a valid CAS Registry Number.
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(E)-3-((R)-4-pyrrolidin-2-yl-phenyl)-acrylic acid methyl ester hydrochloride
