1189164-11-1

Basic information

• Product Name: 1-(3,5-di-tert-butyl-4-methoxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone
• CAS NO: 1189164-11-1
• Molecular Weight: 479.663
• Mol File: 1189164-11-1.mol

Chemical Properties

• CAS DataBase Reference: 1-(3,5-di-tert-butyl-4-methoxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3,5-di-tert-butyl-4-methoxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone(1189164-11-1)
• EPA Substance Registry System: 1-(3,5-di-tert-butyl-4-methoxyphenyl)-2-(2-(3-hydroxypropylamino)-5,6-dimethyl-1H-benzo[d]imidazol-1-yl)ethanone(1189164-11-1)

Safety Data

• Hazardous Substances Data: 1189164-11-1(Hazardous Substances Data)

Upstream product

• 301163-47-3 3-((5,6-dimethyl-1H-benzo[d]imidazol-2-yl)amino)propan-1-ol 
• 940291-86-1 2-bromo-1-(3,5-di-tert-butyl-4-methoxyphenyl)ethanone 

Relevant articles and documents

Selective benzimidazole inhibitors of the antigen receptor-mediated NF-κB activation pathway

Dysregulated antigen receptor-mediated NF-κB activation can contribute to development of autoimmunity, chronic inflammation, and malignancy. A chemical biology screening strategy has identified a substituted benzimidazole that selectively inhibits antigen receptor-mediated NF-κB activation without blocking other NF-κB activation pathways. A library of analogs was synthesized and the structure-activity relationship and metabolic stability for the series is presented.

INHIBITORS OF ANTIGEN RECEPTOR-INDUCED NF-kappa B ACTIVATION

A method to identify selective inhibitors of antigen receptor-mediated NF-κB activation is provided, as well as compositions having one or more of those inhibitors and methods of using those inhibitors.