1189164-22-4Relevant academic research and scientific papers
Selective benzimidazole inhibitors of the antigen receptor-mediated NF-κB activation pathway
Okolotowicz, Karl J.,Shi, Ranxin,Zheng, Xueying,MacDonald, Mary,Reed, John C.,Cashman, John R.
experimental part, p. 1918 - 1924 (2010/05/17)
Dysregulated antigen receptor-mediated NF-κB activation can contribute to development of autoimmunity, chronic inflammation, and malignancy. A chemical biology screening strategy has identified a substituted benzimidazole that selectively inhibits antigen receptor-mediated NF-κB activation without blocking other NF-κB activation pathways. A library of analogs was synthesized and the structure-activity relationship and metabolic stability for the series is presented.
