1189169-37-6

Basic information

• Product Name: 1-(5-bromopyrimidin-2-yl)ethanone
• Synonyms: 1-(5-bromopyrimidin-2-yl)ethanone;1-(5-BroMo-2-pyriMidinyl)ethanone;1-(5-broMopyriMidin-2-yl)ethan-1-one
• CAS NO: 1189169-37-6
• Molecular Formula: C₆H₅BrN₂O
• Molecular Weight: 201
• EINECS: 100-205-4
• Mol File: 1189169-37-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 318.6±34.0 °C(Predicted)
• Appearance: /
• Density: 1.626±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -2.43±0.22(Predicted)
• CAS DataBase Reference: 1-(5-bromopyrimidin-2-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-bromopyrimidin-2-yl)ethanone(1189169-37-6)
• EPA Substance Registry System: 1-(5-bromopyrimidin-2-yl)ethanone(1189169-37-6)

Safety Data

• Hazardous Substances Data: 1189169-37-6(Hazardous Substances Data)

Usage

General Description

1-(5-bromopyrimidin-2-yl)ethanone, also known as 5-Acetyl-5-bromo-1,3-dihydro-2H-pyrimidin-2-one, is a chemical compound commonly used in organic and pharmaceutical synthesis. 1-(5-bromopyrimidin-2-yl)ethanone belongs to the family of Pyrimidinones which are polycyclic aromatic compounds containing a pyrimidine ring, which is a diazine with an oxo group attached to two carbon atoms. The presence of bromine atoms enables it to act as a perfect site for cross-coupling. The CAS number, an identifier for this chemical, is 36048-32-9. Little information is available about its hazards or safety measures, which indicates the requirement for proper handling and caution while using it in experiments.

Upstream product

• 75-16-1 methylmagnesium bromide 
• 38275-57-9 5-bromopyrimidine-2-carbonitrile 
• 97674-02-7 tributyl(1-ethoxyvinyl)stannane 
• 183438-24-6 5-bromo-2-iodopyrimidine 
• 1072-97-5 5-bromo-2-pyridylamine 

Downstream Products

• 1429182-07-9 1-(5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl)ethan-1-one 
• 1429182-15-9 1-(5-(4-fluoro-3-methylphenyl)pyrimidin-2-yl)ethan-1-amine 
• 1429182-10-4 1-(5-(3-(trifluoromethyl)phenyl)pyrimidin-2-yl)ethanamine 
• 1601471-92-4 2,3-dichloro-N-(2-(2-(1,1-difluoroethyl)pyrimidin-5-yl)-2-(4,4-difluoropiperidin-1-yl)ethyl)benzamide 
• 1429182-02-4 1-(5-(3-(trifluoromethyl)phenyl)pyrimidin-2-yl)ethanone 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS AS MUTANT IDH INHIBITORS

The present disclosure relates generally to compounds useful in treatment of conditions associated with mutant isocitrate dehydrogenase (mt-IDH), particularly mutant IDH1 enzymes. Specifically, the present invention discloses compound of formula (IA), which exhibits inhibitory activity against mutant IDH1 enzymes. Method of treating conditions associated with excessive activity of mutant IDH1 enzymes with such compound is disclosed. Uses thereof, pharmaceutical composition, and kits are also disclosed.

FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

A series of fused tricyclic imidazole derivatives, in particular dihydro-1H-cyclopenta[4,5]imidazo[1,2-a]pyridine derivatives, and analogues thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.

Cyclic Amines

The present invention is directed to novel cyclic amines which inhibit the P2X7 receptor.