1189175-68-5

Upstream product

• 1189175-69-6 (3,4-difluorophenyl)[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]methanone 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Downstream Products

• 1258524-18-3 N-{(1R)-1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2,2-trifluoroethyl}-(R)-2-methyl-2-propanesulfinamide 
• 1258524-19-4 N-{(1S)-1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2,2-trifluoroethyl}-(R)-2-methyl-2-propanesulfinamide 
• 1258523-20-4 N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]ethyl}-(R)-2-methyl-2-propanesulfinamide 
• 1189176-01-9 N-[1-[5-({[tert-butyl(dimethyl)silyl]oxy}methyl)pyridin-2-yl]-1-(3,4-difluorophenyl)-2,2,2-trifluoroethyl]-(R)-2-methylpropane-2-sulfinamide 
• 1258523-25-9 N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl}-(R)-2-methyl-2-propanesulfinamide 
• 1258523-24-8 N-{1-(3,4-difluorophenyl)-1-[5-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-2-pyridinyl]-2,2-difluoroethyl-2-(phenylsulfonyl)ethyl}-(R)-2-methyl-2-propanesulfinamide 

Relevant academic research and scientific papers

DIARYLMETHYLAMIDE DERIVATIVE HAVING ANTAGONISTIC ACTIVITY ON MELANIN-CONCENTRATING HORMONE RECEPTOR

[Problem] To provide a melanin-concentrating hormone receptor antagonist useful as a pharmaceutical agent for central diseases, circulatory diseases, and metabolic diseases. [Means for Resolution] Provided is a diarylmethylamide derivative represented by

DIARYLAMIDE-SPIRODIAMINE DERIVATIVE

To provide a melanin concentrating hormone receptor antagonist useful as medicines for central system disorders, cardiovascular disorders and metabolic disorders. Provided is a compound of a formula (I): wherein R1a and R1b each are