1189178-11-7

Basic information

• Product Name: 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(3,4-dimethoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide
• Synonyms: 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(3,4-dimethoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide
• CAS NO: 1189178-11-7
• Molecular Weight: 509.965
• Mol File: 1189178-11-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(3,4-dimethoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(3,4-dimethoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide(1189178-11-7)
• EPA Substance Registry System: 1-(3-chloro-4-fluorophenyl)-6-methyl-N-(4-methylphenyl)-4-(3,4-dimethoxyphenyl)-3,4-dihydropyrimidin-2(1H)-one-5-carboxamide(1189178-11-7)

Safety Data

• Hazardous Substances Data: 1189178-11-7(Hazardous Substances Data)

Upstream product

• 2415-85-2 3-oxo-N-(p-tolyl)butanamide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Relevant articles and documents

Multi-component synthesis of dihydropyrimidines by iodine catalyst at ambient temperature and in-vitro antimycobacterial activity

An efficient and simple three-component domino synthesis of some new dihydropyrimidines (DHPMs) from aromatic aldehydes, 1,3-dicarbonyl compounds and N-(3-chloro-4-fluorophenyl) urea using molecular iodine as catalyst is described. The 1-substituted dihydropyrimidines were isolated in good to excellent yields (78-90%) within a short reaction time (4-6 h) at ambient temperature. The biological evaluation revealed that the newly synthesized compounds (4a-i and 5a-i) exhibited moderate antimycobacterial activity against Mycobacterium tuberculosis H37 RV.