1189196-22-2

Upstream product

• 1676-81-9 N-benzyloxycarbonyl-L-serine methyl ester 

Downstream Products

• 90035-60-2 (L)-N-Z-azidoalanine methyl ester 
• 1380336-84-4 methyl (S)-2-(((benzyloxy)carbonyl)amino)-3-(4-(4-chlorophenyl)-1H-1,2,3-triazol-1-yl)propanoate 
• 1380336-83-3 methyl (S)-2-(((benzyloxy)carbonyl)amino)-3-(4-phenyl-1H-1,2,3-triazol-1-yl)propanoate 
• 1394239-75-8 methyl (R)-2-(((benzyloxy)carbonyl)amino)-3-((diethylaminocarbothioyl)thio)propanoate 
• 1394239-83-8 methyl (S)-1-((((R)-2-(((benzyloxy)carbonyl)amino)-3-methoxy-3-oxopropyl)thio)carbonothioyl)pyrrolidine-2-carboxylate 

Relevant academic research and scientific papers

A modular synthesis of dithiocarbamate pendant unnatural α-amino acids

Unnatural α-amino acids containing dithiocarbamate side chains were synthesized by a one-pot reaction of in situ generated dithiocarbamate anions with sulfamidates. A wide range of these anions participated in the highly regio- and stereo-selective ring opening of sulfamidates to produce the corresponding dithiocarbamate pendant α-amino acids in high yields.

Stereo- and regio-selective one-pot synthesis of triazole-based unnatural amino acids and β-amino triazoles

Synthesis of triazole based unnatural amino acids and β-amino triazoles has been described via a stereo and regioselective one-pot multi-component reaction of sulfamidates, sodium azide, and alkynes under MW conditions. The developed method is applicable to a broad substrate scope and has significant potential for the synthesis of unnatural amino acids with a triazole side chain.