1189207-30-4 Usage
Description
4-Fluoro-2-(phenylethynyl)benzaldehyde is a chemical compound characterized by the molecular formula C15H9FO. It is a fluoro-substituted benzaldehyde derivative featuring a phenylethynyl group attached to the carbon-2 position. 4-fluoro-2-(phenylethynyl)benzaldehyde is recognized for its unique chemical properties, making it a valuable building block in the synthesis of a variety of pharmaceuticals, agrochemicals, and materials. Its versatility and potential applications across different scientific and industrial contexts highlight its importance in research and development.
Uses
Used in Organic Chemistry:
4-Fluoro-2-(phenylethynyl)benzaldehyde serves as a key building block in the synthesis of various compounds. Its unique structure allows for the creation of a wide range of pharmaceuticals, agrochemicals, and materials, contributing to the advancement of these fields.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-fluoro-2-(phenylethynyl)benzaldehyde is utilized as a precursor for the development of new drugs. Its specific chemical properties enable the design and synthesis of molecules with potential therapeutic effects, addressing unmet medical needs.
Used in Agrochemical Industry:
4-Fluoro-2-(phenylethynyl)benzaldehyde also finds application in the agrochemical sector, where it is employed in the synthesis of novel agrochemicals. Its unique structure aids in the development of compounds with improved pesticidal or herbicidal properties, enhancing crop protection and yield.
Used in Materials Science:
In the field of materials science, 4-fluoro-2-(phenylethynyl)benzaldehyde is used for the development of new materials with specific properties. Its incorporation into material compositions can lead to the creation of materials with tailored characteristics for various applications, such as in electronics or advanced manufacturing.
Used in Research and Development:
4-Fluoro-2-(phenylethynyl)benzaldehyde is extensively used in research and development due to its unique chemical properties and potential applications. It serves as a valuable tool for scientists and researchers to explore new chemical reactions, synthesis pathways, and the development of innovative products across various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 1189207-30-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,9,2,0 and 7 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1189207-30:
(9*1)+(8*1)+(7*8)+(6*9)+(5*2)+(4*0)+(3*7)+(2*3)+(1*0)=164
164 % 10 = 4
So 1189207-30-4 is a valid CAS Registry Number.
1189207-30-4Relevant articles and documents
Catalytic Asymmetric Tandem Reaction of o-Alkynylbenzaldehydes, Amines, and Diazo Compounds
Wu, Wei,Liao, Na,Wei, Qi,Huang, Jiaying,Huang, Qi,Peng, Yungui
supporting information, p. 6872 - 6876 (2021/09/14)
An efficient asymmetric tandem reaction of o-alkynylbenzaldehydes, amines, and diazo compounds catalyzed by chiral silver imidodiphosphate has been established. Chiral 1,2-dihydroisoquinoline analogues have a tertiary stereocenter at the C1 position, and substituents at the C3 position are available with up to 97% yields and 98% ee. These products can be elaborated into the corresponding β-aminophosphonates or PARP1-inhibitor analogues.
Palladium-catalyzed cascade decarboxylative amination/6- endo-dig benzannulation of o-alkynylarylketones with n-hydroxyamides to access diverse 1-naphthylamine derivatives
Zuo, Youpeng,He, Xinwei,Tang, Qiang,Hu, Wangcheng,Zhou, Tongtong,Shang, Yongjia
supporting information, p. 3890 - 3894 (2020/05/18)
An efficient and practical one-pot strategy to produce highly substituted 1-naphthylamines via sequential palladium-catalyzed decarboxylative amination/intramolecular 6-endo-dig benzannulation reactions has been described. In this reaction, a broad range of electron-rich, electron-neutral, and electron-deficient o-alkynylarylketones react well with N-hydroxyl aryl/alkylamides to give a diversity of 1-naphthylamines in good to excellent yields under mild reaction conditions. The gram-scale synthesis, with benefits such as undiminished product yield and easy transformation, illustrated the practicality of this method.
Carbonyl-Directed Addition of N-Alkylhydroxylamines to Unactivated Alkynes: Regio- and Stereoselective Synthesis of Ketonitrones
Liu, Yilin,Feng, Xiangqing,Liu, Yanyun,Lin, Hongwei,Li, Yuanxiang,Gong, Yingying,Cao, Lei,Chen, Liping
supporting information, p. 382 - 386 (2019/01/11)
A variety of ketonitrones were synthesized in moderate to excellent yields with high chemo-, regio-, and stereoselectivity by using carbonyl-directed addition of N-alkylhydroxylamines to unactivated alkynes under mild conditions. The product diverisity could be controlled by the use of different bases, and EtN(n-Pr)2 could promote the formation of ketonitrones while using EtONa as base led to indanone-derived nitrones. Control experiments indicated that the carbonyl group of the substrate acted as an H-bond acceptor except for an electron-withdrawing group, and conjugated enone skeleton accounted for the high selectivity.
