1189260-03-4Relevant academic research and scientific papers
Synthesis, biological evaluation and in silico studies of tetrazole-heterocycle hybrids
Sribalan, Rajendran,Banuppriya, Govindharasu,Kirubavathi, Maruthan,Padmini, Vediappen
, p. 577 - 586 (2019)
The series of three different chemical entities of tetrazole-heterocycle hybrids such as thiophene, pyridine and quinoline tetrazoles were synthesized and characterized for the purpose to develop new lead molecules. Biological evaluations such as in vitro antimicrobial and anti-inflammatory activities were studied. Further, the in silico studies such as Molecular docking (with COX-1, COX-2 and 3TTZ), DFT calculations, the Molecular electrostatic potential (MEP) and ADME were investigated.
Transition-metal-free multinitrogenation of amides by C-C bond cleavage: A new approach to tetrazoles
Li, Lian-Hua,Li, Ying-Xiu,Liang, Yong-Min,Niu, Zhi-Jie
supporting information, p. 11148 - 11151 (2020/04/22)
A metal-free brand-new one-pot multinitrogenation of amides for the chemo- A nd regioselective synthesis of 1,5-disubstituted tetrazoles has been developed. By means of electrophilic amide activation, and further C-C bond cleavage and rearrangement, a diverse set of functionalized 1,5-DST derivatives were selectively constructed under mild conditions. As showcased in the mechanisms, the chemoselectivity is easily switched by the selection of the starting materials in the reaction.
Direct C-H arylation and alkenylation of 1-substituted tetrazoles: Phosphine as stabilizing factor
Spulak, Marcel,Lubojacky, Richard,Senel, Petr,Kunes, Jiri,Pour, Milan
experimental part, p. 241 - 244 (2010/04/06)
(Chemical Equation Presented) Direct arylation and alkenylation of 1-substituted tetrazoles was achieved via Pd catalysis in the presence of CuI and Cs2CO3. Unlike the related reactions of imidazoles and purines, phosphine ligand was
Synthesis of 1,5-disubstituted tetrazoles via Suzuki-Miyaura cross-coupling of 5-chloro-1-phenyltetrazole
Tang, Qing,Gianatassio, Ryan
experimental part, p. 3473 - 3476 (2010/08/20)
Suzuki-Miyaura coupling reactions of 5-chloro-1-phenyl-tetrazole with various functionalized arylboronic acids were investigated. In the presence of catalytic amounts of SPhos/Pd(OAc)2 or RuPhos/Pd(OAc)2, the reaction proceeded smoot
