118930-99-7Relevant articles and documents
DUPA Conjugation of a Cytotoxic Indenoisoquinoline Topoisomerase i Inhibitor for Selective Prostate Cancer Cell Targeting
Roy, Jyoti,Nguyen, Trung Xuan,Kanduluru, Ananda Kumar,Venkatesh, Chelvam,Lv, Wei,Reddy, P. V. Narasimha,Low, Philip S.,Cushman, Mark
, p. 3094 - 3103 (2015/04/27)
(Figure Presented). Prostate-specific membrane antigen (PSMA) is overexpressed in most prostate cancer cells while being present at low or undetectable levels in normal cells. This difference provides an opportunity to selectively deliver cytotoxic drugs
CONJUGATES AND COMPOSITIONS FOR DRUG DELIVERY
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Paragraph 120, (2015/08/03)
The present invention provides folate receptor binding ligand‐drug delivery conjugates having the formula (F) nL1L2D. The conjugates have high affinity to folate receptor‐positive tumor cells and low toxicity for normal ce
Design and synthesis of releasable folate-drug conjugates using a novel heterobifunctional disulfide-containing linker
Satyam, Apparao
supporting information; experimental part, p. 3196 - 3199 (2009/04/11)
Cellular uptake of vitamin folic acid occurs via folate-receptor mediated endocytosis. Many types of cancer cells express high levels of folate receptors as they need continuous supply of this vitamin for their proliferation. With an objective to use foli
