1189344-75-9Relevant academic research and scientific papers
Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies
Gemma, Sandra,Savini, Luisa,Altarelli, Maria,Tripaldi, Pierangela,Chiasserini, Luisa,Coccone, Salvatore Sanna,Kumar, Vinod,Camodeca, Caterina,Campiani, Giuseppe,Novellino, Ettore,Clarizio, Sandra,Delogu, Giovanni,Butini, Stefania
, p. 6063 - 6072 (2009)
A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25 μg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results.
