1189366-29-7Relevant academic research and scientific papers
Synthesis of tipranavir analogues as non-peptidic HIV protease inhibitors
Ding, Yili,Vara Prasad, Chamakura V.N.S.,Smith, Kenneth L.,Chang, Eugene,Hong, Jian,Yao, Nanhua
scheme or table, p. 130 - 133 (2010/04/23)
An analogue of Tipranavir was designed by replacing the dihydropyrone core with a 1,3-cyclohexanedione ring. The thio-alky1 group was used as a temporary protection group for α, β-unsaturated cyclohexane-1,3-diketone derivative, and the resulting compound was reacted with an ethyl-organometallic reagent to form the desired Michael addition product. By using this strategy, a more stable analogue of Tipranavir was synthesized and exhibited excellent HIV protease inhibition (12 nM Ki).
