1189372-41-5Relevant academic research and scientific papers
Synthesis of 4-mercapto-l-lysine derivatives: Potential building blocks for sequential native chemical ligation
Pasunooti, Kalyan Kumar,Yang, Renliang,Vedachalam, Seenuvasan,Gorityala, Bala Kishan,Liu, Chuan-Fa,Liu, Xue-Wei
, p. 6268 - 6271 (2009)
A general and diastereoselective synthesis of (2S, 4S)-4-mercapto-l-lysine derivative was described. The key features of this synthesis include Zn-mediated diastereoselective Reformatsky reaction and selective reduction of methyl ester with sodium borohyd
Synthesis of K48-linked diubiquitin using dual native chemical ligation at lysine
Yang, Renliang,Pasunooti, Kalyan Kumar,Li, Fupeng,Liu, Xue-Wei,Liu, Chuan-Fa
supporting information; experimental part, p. 7199 - 7201 (2010/11/16)
The dual native chemical ligation at lysine strategy was revised by replacing the acid-labile Cbz protecting group with photolabile NVOC at the 4-mercaptolysine side chain. The optimized strategy was subsequently applied to the synthesis of K48-linked diu
Dual native chemical ligation at lysine
Yang, Renliang,Pasunooti, Kalyan Kumar,Li, Fupeng,Liu, Xue-Wei,Liu, Chuan-Fa
supporting information; experimental part, p. 13592 - 13593 (2010/01/06)
(Chemical Presented) A thiol group introduced on the γ-carbon of lysine mediates robust native chemical ligation at both the α- and ε-amines in two consecutive steps. Desulfurization then affords the final product, in which the lysine residue at the ligat
