1189378-24-2Relevant articles and documents
Regioselective cleavage of 2-aryloxymethyloxiranes to 3-aryloxy-l- halogenopropan-2-ols
Maciejewski,Poltorak,Kaminska
experimental part, p. 595 - 604 (2009/12/26)
A series of new 2-ary loxymethy loxiranes prepared from epichlorohydrin and substituted phenols was subjected to nucleophilic opening of the oxirane ring. A comparison of regioselectivity and product yield for oxirane cleavage by means of aqueous hydrohalogenic acids or lithium tetrahalogenocuprates under anhydrous conditions was performed. The latter method provided very high regioselectivity for 3-aryloxy-l-halo-genopropan-2-ols as well as excellent yields.
