1189394-17-9Relevant academic research and scientific papers
Glutathione reductase-catalyzed cascade of redox reactions to bioactivate potent antimalarial 1,4-naphthoquinones - A new strategy to combat malarial parasites
Mueller, Tobias,Johann, Laure,Jannack, Beate,Brueckner, Margit,Lanfranchi, Don Antoine,Bauer, Holger,Sanchez, Cecilia,Yardley, Vanessa,Deregnaucourt, Christiane,Schrevel, Joseph,Lanzer, Michael,Schirmer, R. Heiner,Davioud-Charvet, Elisabeth
, p. 11557 - 11571 (2011)
Our work on targeting redox equilibria of malarial parasites propagating in red blood cells has led to the selection of six 1,4-naphthoquinones, which are active at nanomolar concentrations against the human pathogen Plasmodium falciparum in culture and a
Redox Polypharmacology as an Emerging Strategy to Combat Malarial Parasites
Sidorov, Pavel,Desta, Israel,Chessé, Matthieu,Horvath, Dragos,Marcou, Gilles,Varnek, Alexandre,Davioud-Charvet, Elisabeth,Elhabiri, Mourad
supporting information, p. 1339 - 1351 (2016/07/22)
3-Benzylmenadiones are potent antimalarial agents that are thought to act through their 3-benzoylmenadione metabolites as redox cyclers of two essential targets: the NADPH-dependent glutathione reductases (GRs) of Plasmodium-parasitized erythrocytes and m
1,4-NAPHTHOQUINONE DERIVATIVES AND THERAPEUTIC USE THEREOF
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Page/Page column 28, (2009/10/22)
Derivatives of formula (I) wherein A is selected from the following rings: and their preparation and their application as antimalarial agents.
