118946-50-2

Basic information

• Product Name: 1,2-Dihydro-2-(4-methylphenyl)-5-phenyl-3H-1,2,4-triazol-3-one
• Synonyms: 1,2-Dihydro-2-(4-methylphenyl)-5-phenyl-3H-1,2,4-triazol-3-one;1,2-Dihydro-2-(4-methylphenyl)-5-phenyl-3H-1,2,4-
• CAS NO: 118946-50-2
• Molecular Formula: C15H13N3O
• Molecular Weight: 251.28322
• Mol File: 118946-50-2.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Density: 1.225g/cm³
• Refractive Index: 1.649
• CAS DataBase Reference: 1,2-Dihydro-2-(4-methylphenyl)-5-phenyl-3H-1,2,4-triazol-3-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Dihydro-2-(4-methylphenyl)-5-phenyl-3H-1,2,4-triazol-3-one(118946-50-2)
• EPA Substance Registry System: 1,2-Dihydro-2-(4-methylphenyl)-5-phenyl-3H-1,2,4-triazol-3-one(118946-50-2)

Safety Data

• Hazardous Substances Data: 118946-50-2(Hazardous Substances Data)

Usage

General Description

1,2-Dihydro-2-(4-methylphenyl)-5-phenyl-3H-1,2,4-triazol-3-one, also known as bezitramide, is a synthetic opioid analgesic drug. It belongs to the class of 4-phenylpiperidine and is structurally similar to other opioid drugs such as pethidine and ketobemidone. Bezitramide is commonly used for the management of moderate to severe pain, and it works by binding to the mu-opioid receptors in the brain and spinal cord, thereby blocking the transmission of pain signals. However, it also carries a high potential for abuse and dependence, and prolonged use can lead to tolerance, addiction, and withdrawal symptoms. As a result, it is typically prescribed for short-term pain relief and under strict medical supervision.

InChI:InChI=1/C15H13N3O/c1-11-7-9-13(10-8-11)18-15(19)16-14(17-18)12-5-3-2-4-6-12/h2-10H,1H3,(H,16,17,19)

Upstream product

• 637-60-5 p-tolylhydrazine hydrochloride 
• 65-85-0 benzoic acid 
• 108-73-6 3,5-dihydroxyphenol 

Relevant articles and documents

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.