118974-02-0 Usage
Uses
Different sources of media describe the Uses of 118974-02-0 differently. You can refer to the following data:
1. Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Recent research has determined fumitremorgin C as a potent inhibitor of the breast cancer resistance protein BCRP/ABCG2
multidrug transporter.
2. Fumitremorgin C is a tremorgenic mycotoxin isolated from Aspergillus fumigatus. Recent research has determined fumitremorgin C as a potent inhibitor of the breast cancer resistance protein BCRP/ABCG2 multidrug transporter.
Definition
ChEBI: An organic heteropentacyclic compound that is a mycotoxic indole alkaloid produced by several fungi. A potent and specific inhibitor of the breast cancer resistance protein multidrug transporter.
General Description
A cell-permeable indolyldiketopiperazinyl mycotoxin that inhibits BCRP/ABCG2 (breast cancer resistance protein/ATP-binding cassette G2) multidrug transport activity. Also acts as a potent and specific chemosenzitizing agent.
Biochem/physiol Actions
Cell permeable: yes
Check Digit Verification of cas no
The CAS Registry Mumber 118974-02-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,8,9,7 and 4 respectively; the second part has 2 digits, 0 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 118974-02:
(8*1)+(7*1)+(6*8)+(5*9)+(4*7)+(3*4)+(2*0)+(1*2)=150
150 % 10 = 0
So 118974-02-0 is a valid CAS Registry Number.
118974-02-0Relevant articles and documents
Antibacterial activity of diketopiperazines isolated from a marine fungus using t-butoxycarbonyl group as a simple tool for purification
El-Gendy, Bahaa El-Dien M.,Rateb, Mostafa E.
, p. 3125 - 3128 (2015)
Abstract Nine diketopiperazines were characterized from the culture of marine fungal isolate MR2012 which based on DNA amplification and sequencing of the fungal internal transcribed spacer (ITS) region was identified as Aspergillus fumigatus. The isolated fungal metabolites 4-12 were unambiguously identified as a series of simple and re-arranged diketopiperazines by analysis of spectroscopic data. t-Butoxycarbonyl group (BOC) derivatization was used to separate the intractable mixture of 4 and 5. When all compounds were evaluated for antimicrobial activity against gram positive bacteria, the isolated metabolites showed moderate to weak effects, while the semisynthetic derivatives 4a and 5a displayed strong activity comparable to the positive control, tetracycline against gram positive bacteria.
FIRST TOTAL SYNTHESIS OF (-)-FUMITREMORGIN
Hermkens, Pedro H. H.,Plate, Ralf,Ottenheijm, Harry C. J.
, p. 1991 - 2000 (2007/10/02)
The first total synthesis of the tremorgic mycotoxin fumitremorgin C (1a) employing 6-methoxy-N-hydroxytryptophan (5a) is presented.Our approach features formation of the nitrone (6a), stereoselective cycloaddition to yield (7a), ring opening and coupling
