118974-47-3Relevant academic research and scientific papers
Synthesis and in vitro antitumor activity of novel 2-alkyl-5- methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-alkylellipticin-2-ium chloride derivatives
Mori, Ryota,Kato, Asako,Komenoi, Kousuke,Kurasaki, Haruaki,Iijima, Touru,Kawagoshi, Masashi,Kiran,Takeda, Sho,Sakai, Norio,Konakahara, Takeo
, p. 16 - 35 (2014/06/09)
Twenty-one types of novel ellipticine derivatives and pyridocarbazoles (5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazoles) with a nitrosourea moiety, linked by an oxydiethylene unit at the 2 position, were synthesized, and their cytotoxicity against HeLa S-3 cells was evaluated. Some of these new compounds exhibited potent antitumor activity by comparison with that of ellipticine.
A New Building Block Method to Synthesize Symmetrical and Asymmetrical Per-N-alkyl-Substituted Polyaza-Crown Compounds
Krakowiak, Krzysztof E.,Bradshaw, Jerald S.,Izatt, Reed M.,Zamecka-Krakowiak, Daria J.
, p. 4061 - 4067 (2007/10/02)
A new approach for the synthesis of a variety of per-N-alkylated polyaza-crown compounds is decscribed.N-acetamide (25) and its benzamide analogue 26 are the key building blocks for the synthesis of the new polyaza-crowns.These ch
NOVEL AND CONVENIENT SYNTHESES OF N-ALKYL-SUBSTITUTED TRIAZA- AND TETRAAZA-CROWN COMPOUNDS
Krakowiak, Krzysztof E.,Bradshaw, Jerald S.,Izatt, Reed M.
, p. 3521 - 3524 (2007/10/02)
A new short method to prepare N-alkyl-substituted triaza- and tetraaza-crown compounds in good overall yield by reacting the appropriate oligoazaoxadiamine with allyloxymethyl-substituted triethylene glycol diiodide or diglycolyl dichloride (followed by r
