118975-51-2Relevant academic research and scientific papers
Oxidation of 1-hydroxyazetidines to four-membered cyclic nitrones and β-lactams
Elburg, P. A. van,Reinhoudt, D. N.
, p. 381 - 387 (2007/10/02)
The 1-(benzyloxy)azetidines 7a-c and 16a,b were synthesized by reductive cyclization of the corresponding oximes 5a-c and 14a-d.Oxidation of the 1-hydroxyazetidines 8a-c and 17 with PbO2 afforded the corresponding four-membered cyclic nitrones 18a-c and t
ACETOXYLATION OF 1-BENZYLOXY β-LACTAMS AT C-4 VIA A REDUCTION-OXIDATION SEQUENCE
Elburg, Paulus A. van,Reinhoudt, David N.
, p. 437 - 445 (2007/10/02)
Selective dihydroalane reduction of 1-benzyloxy β-lactams 4 affords 1-(benzyloxy)azetidines 6 which can be debenzylated to give the 1-hydroxy azetidines 7.Oxidation of the compounds 7 either gives a mixture of β-lactams 10 and 11 or selectively β-lactams
