1189791-42-1Relevant articles and documents
RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: Design, biochemical activity, and structural information
Kirschberg, Thorsten A.,Balakrishnan, Mini,Squires, Neil H.,Barnes, Tiffany,Brendza, Katherine M.,Chen, Xiaowu,Eisenberg, Eugene J.,Jin, Weili,Kutty, Nilima,Leavitt, Stephanie,Liclican, Albert,Liu, Qi,Liu, Xiaohong,Mak, John,Perry, Jason K.,Wang, Michael,Watkins, William J.,Lansdon, Eric B.
, p. 5781 - 5784 (2009)
Pyrimidinol carboxylic acids were designed as inhibitors of HIV-1 RNase H function. These molecules can coordinate to two divalent metal ions in the RNase H active site. Inhibition of enzymatic activity was measured in a biochemical assay, but no antivira
