1189858-48-7

Basic information

• Product Name: 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide
• Synonyms: 4-Chloro-N-(methyld3)-2-pyridinecarboxamide;4-Chloro-N-(methyl-d3)picolinamide;4-Chloro-N-(methyl-d3)pyridine-2-carboxamide;4-Chloropyridine-2-carboxylic Acid (Methyl-d3)amide;N-(Methyl-d3)-4-chloro-2-pyridinecarboxamid;N-(Methyl-d3)-4-chloro-2-pyridinecarboxamide
• CAS NO: 1189858-48-7
• Molecular Formula: C₇H₇ClN₂O
• Molecular Weight: 170.59628
• Product Categories: Chemical Amines;Amines;Aromatics;Heterocycles;Isotope Labeled Compounds;Isotope Labelled Compounds
• Mol File: 1189858-48-7.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Ethyl Acetate, Methanol (Slightly)
• CAS DataBase Reference: 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide(1189858-48-7)
• EPA Substance Registry System: 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide(1189858-48-7)

Safety Data

• Hazardous Substances Data: 1189858-48-7(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

4-Chloro-N-(methyl-d3)pyridine-2-carboxamide (cas# 1189858-48-7) is a compound useful in organic synthesis.

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 5581-55-5 Methylamin-C-D₃ 
• 5470-22-4 4-chloropicolinic acid 
• 7436-22-8 methyl-d3-amine hydrochloride 
• 98-98-6 2-Picolinic acid 
• 53750-66-6 4-chloro-pyridine-2-carbonyl chloride 
• 59-67-6 nicotinic acid 
• 176977-85-8 methyl 4-chloropyridine-2-carboxylate hydrochloride 

Downstream Products

• 1130115-44-4 N-(4-chloro-3-(trifluoromethyl)phenyl)-N'-(4-(2-(N-(methyl-d₃)aminoformyl)-4-pyridyloxy)phenyl)urea 
• 1189975-18-5 4-(4-aminophenoxy)-2-pyridine-(N-(methyl-d₃))carboxamide 
• 1257864-28-0 4-(4-amino-3-fluorophenoxy)-N-(methyl-d₃)picolinamide 
• 1333386-18-7 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide p-toluenesulfonate 
• 1333386-17-6 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)phenoxyl)-2-(N-1’,1’,1’-trideuteromethyl)pyridine amide p-toluenesulfonate 
• 1333489-03-4 C₂₁H₁₂⁽²⁾H₃ClF₄N₄O₄ 
• 1333488-98-4 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluoro-phenoxy)-N-(methyl-d₃)picolinamide hydrochloride 
• 1333390-47-8 C₂₁H₁₂⁽²⁾H₃ClF₄N₄O₃*CH₄O₃S 
• 1255386-16-3 4-(4-(3-(4-chloro-3-trifluoromethylphenyl)ureido)-3-fluorophenoxy)-2-(N-1',1',1'-trideuteromethyl)pyridine amide 
• 1333489-01-2 phenyl 2-fluoro-4-(2-((methyl-d₃)carbamoyl)pyridin-4-yloxy)phenylcarbamate 

Relevant articles and documents

Synthesis of deuterium-enriched sorafenib derivatives and evaluation of their biological activities

Deuterium substitution has been widely known that can improve the pharmacokinetic profiles due to isotope effect. Herein, a series of deuterated sorafenib derivatives have been synthesized and characterized by 1H NMR, 13C NMR and MS. Their antitumor activities were evaluated in vitro against human hepatoma cell line HepG2 and human cervical carcinoma cell line HeLa. The LogP values were detected by high-performance liquid chromatography. Subsequently, the metabolic stability and pharmacokinetics study were assessed in vitro and in vivo.

Deuterated bisarylurea compound and preparation method thereof, and application of compound in preparation of antitumor drug

The invention provides a deuterated bisarylurea compound and a preparation method thereof, and application of the compound in preparation of an antitumor drug. The compound has a structure as shown in a general formula (I). The preparation method comprises the following steps: with methyl 4-chloropyridine-2-formate as a raw material, sucjecting methyl 4-chloropyridine-2-formate and methylamine or deuterated methylamine to a substitution reaction; then subjecting a product obtained in the previous step to condensation with p-aminophenol or deuterated p-aminophenol; and reacting a product obtained in the previous step with 4-chloro-3-(trifluoromethyl)phenyl isocyanate or deuterated 4-chloro-3-(trifluoromethyl)phenyl isocyanate so as to prepare the deuterated bisarylurea compound. Experiment results show that the deuterated bisarylurea compound provided by the invention has tumor treatment effect. The invention also provides application of the compound to research and development of the antitumor drug.

PREPARATION METHOD OF FLUORO-SUBSTITUTED DEUTERATED DIPHENYLUREA

A fluoro-substituted deuterated diphenylurea compound, especially 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-2-(N-(methyl-d3))picolinamide, preparing method and use for treating or preventing tumor and relative diseases thereof.