118988-05-9

Upstream product

• 118988-04-8 ethyl 2-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-acetate 
• 98-59-9 p-toluenesulfonyl chloride 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 

Downstream Products

• 142504-45-8 benzyl <2-<2-(2-iodoethoxy)ethoxy>ethoxy>acetate 
• 142504-50-5 ethyl <2-<2-<2-(4-carboxyphenyloxy)ethoxy>ethoxy>ethoxy>acetate 
• 142504-54-9 (2-{2-[2-(4-Chlorocarbonyl-phenoxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid ethyl ester 
• 142504-52-7 4-{2-[2-(2-Benzyloxycarbonylmethoxy-ethoxy)-ethoxy]-ethoxy}-benzoic acid 
• 142504-56-1 (2-{2-[2-(4-Chlorocarbonyl-phenoxy)-ethoxy]-ethoxy}-ethoxy)-acetic acid benzyl ester 
• 142504-48-1 benzyl <2-<2-<2-<4-(allyloxycarbonyl)phenyloxy>ethoxy>ethoxy>ethoxy>acetate 
• 142504-46-9 ethyl <2-<2-<2-<4-(benzyloxycarbonyl)phenyloxy>ethoxy>ethoxy>ethoxy>acetate 
• 118988-09-3 [2-(2-{2-[2-(Benzyloxycarbonyl-butyl-amino)-acetylamino]-ethoxy}-ethoxy)-ethoxy]-acetic acid ethyl ester 
• 118988-12-8 [2-(2-{2-[2-({3-Amino-5-[butyl-({2-[2-(2-ethoxycarbonylmethoxy-ethoxy)-ethoxy]-ethylcarbamoyl}-methyl)-carbamoyl]-benzoyl}-butyl-amino)-acetylamino]-ethoxy}-ethoxy)-ethoxy]-acetic acid ethyl ester 
• 118988-11-7 [2-(2-{2-[2-(Butyl-{3-[butyl-({2-[2-(2-ethoxycarbonylmethoxy-ethoxy)-ethoxy]-ethylcarbamoyl}-methyl)-carbamoyl]-5-nitro-benzoyl}-amino)-acetylamino]-ethoxy}-ethoxy)-ethoxy]-acetic acid ethyl ester 

Relevant academic research and scientific papers

BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

THE "CHUNDLE" APPROACH TO MOLECULAR CHANNELS SYNTHESIS OF A MACROCYCLE-BASED MOLECULAR BUNDLE

A molecular sheaf 7 formed by bundles of oligo(oxyethylene) chains grafted on a macrocyclic polyether has been synthesized; its structural features characterize an approach to the design of transmambrane molecular channels.