1189922-22-2 Usage
Uses
Used in Pharmaceutical Industry:
2-(4'-fluorobiphenyl-4-yl)ethanaMine hydrochloride is used as a reagent for the identification and optimization of a new series of anti-tubercular quinazolines. Its unique structure and reactivity enable the development of novel therapeutic agents targeting tuberculosis, a disease that poses significant global health challenges.
In the context of anti-tubercular drug development, 2-(4'-fluorobiphenyl-4-yl)ethanaMine hydrochloride serves as a crucial intermediate in the synthesis of quinazolines, which are known for their potent anti-tubercular activity. The compound aids in the structural modification and enhancement of the pharmacological properties of these quinazolines, ultimately leading to the discovery of more effective and safer anti-tubercular drugs.
Furthermore, the compound's potential applications may extend to other areas within the pharmaceutical industry, such as the development of new drugs for other infectious diseases or the synthesis of novel compounds with diverse therapeutic applications. However, further research and development are necessary to fully explore and understand the compound's capabilities and potential in these areas.
Check Digit Verification of cas no
The CAS Registry Mumber 1189922-22-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,8,9,9,2 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1189922-22:
(9*1)+(8*1)+(7*8)+(6*9)+(5*9)+(4*2)+(3*2)+(2*2)+(1*2)=192
192 % 10 = 2
So 1189922-22-2 is a valid CAS Registry Number.
1189922-22-2Relevant academic research and scientific papers
Synthesis and evaluation of biaryl derivatives for structural characterization of selective monoamine oxidase B inhibitors toward Parkinson's disease therapy
Yeon, Seul Ki,Choi, Ji Won,Park, Jong-Hyun,Lee, Ye Rim,Kim, Hyeon Jeong,Shin, Su Jeong,Jang, Bo Ko,Kim, Siwon,Bahn, Yong-Sun,Han, Gyoonhee,Lee, Yong Sup,Pae, Ae Nim,Park, Ki Duk
, p. 232 - 244 (2017/12/08)
Benzyloxyphenyl moiety is a common structure of highly potent, selective and reversible inhibitors of monoamine oxidase B (MAO-B), safinamide and sembragiline. We synthesized 4-(benzyloxy)phenyl and biphenyl-4-yl derivatives including halogen substituents on the terminal aryl unit. In addition, we modified the carbon linker between amine group and the biaryl linked unit. Among synthesized compounds, 12c exhibited the most potent and selective MAO-B inhibitory effect (hMAO-B IC50: 8.9 nM; >10,000-fold selectivity over MAO-A) as a competitive inhibitor. In addition, 12c showed greater MAO-B inhibitory activity and selectivity compared to well-known MAO-B inhibitors such as selegiline, safinamide and sembragiline. In the MPTP-induced mouse model of Parkinson's disease (PD), 12c significantly protected the tyrosine hydroxylase (TH)-immunopositive DAergic neurons and attenuated the PD-associated behavioral deficits. This study suggests characteristic structures as a MAO-B inhibitor that may provide a good insight for the development of therapeutic agents for PD.
