119-54-0 Usage
General Description
PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE, also known as Diethylcarbamazine, is a synthetic organic compound with anti-parasitic properties. It is commonly used as a medication to treat infections caused by various types of parasitic worms, including filarial worms, which can cause diseases such as lymphatic filariasis and onchocerciasis. Diethylcarbamazine works by paralyzing and killing the worms, thus helping to eliminate the infection. It is typically administered orally in the form of tablets or liquid suspension. While generally well-tolerated, some common side effects may include nausea, vomiting, and dizziness. PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE has been included in the World Health Organization's list of essential medicines, making it an important tool in the treatment and control of parasitic infections.
Check Digit Verification of cas no
The CAS Registry Mumber 119-54-0 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,1 and 9 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 119-54:
(5*1)+(4*1)+(3*9)+(2*5)+(1*4)=50
50 % 10 = 0
So 119-54-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H19N3O/c1-3-11(4-2)9(13)12-7-5-10-6-8-12/h10H,3-8H2,1-2H3
119-54-0Relevant articles and documents
Insertion of arynes into N-halo bonds: A direct approach to O -haloaminoarenes
Hendrick, Charles E.,McDonald, Stacey L.,Wang, Qiu
, p. 3444 - 3447 (2013/07/26)
A new approach to access o-haloaminoarenes has been achieved by insertion of arynes into a nitrogen-halide bond (N-X). This transition-metal-free transformation displays a broad substrate scope of arynes, good compatibility with functional groups, and high regioselectivity. Representative transformations of the o-haloaminoarenes are described to highlight their utility for rapid access to diversely functionalized aminoarene derivatives.
Studies in Potential Filaricides: Part XV - Synthesis of 1-Acyl/Aryl-4-substituted-piperazines as Diethylcarbamazine Analogs
Agrawal, V. K.,Sharma, Satyavan
, p. 650 - 654 (2007/10/02)
1-Acyl-4-substituted-piperazines (4-29) have been prepared starting from 1-benzylpiperazine while 1-aryl-4-aroylpiperazines (30-44) have been obtained from the corresponding 1-arylpiperazines.None of the compounds shows any significant filaricidal activity against Litomosoides carinii in cotton rats and cestodicial activity against Hymenolepis nana in mice.
