119-54-0

Usage

Uses

Used in Pharmaceutical Industry:
PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE is used as an anti-parasitic medication for the treatment of infections caused by various parasitic worms. It is particularly effective against filarial worms, which can lead to serious diseases such as lymphatic filariasis and onchocerciasis. PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE works by paralyzing and killing the worms, thus helping to eliminate the infection.
Used in Public Health Initiatives:
PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE is used as a key component in public health programs aimed at controlling and preventing parasitic infections. Its inclusion in the World Health Organization's list of essential medicines highlights its importance in global health efforts to combat parasitic diseases.
Used in Research and Development:
PIPERAZINE-1-CARBOXYLIC ACID DIETHYLAMIDE is utilized in research settings to study the mechanisms of action against parasitic worms and to develop new treatments or improvements to existing therapies for parasitic infections. Its role in scientific inquiry contributes to the advancement of medical knowledge and the development of more effective anti-parasitic strategies.

InChI:InChI=1/C9H19N3O/c1-3-11(4-2)9(13)12-7-5-10-6-8-12/h10H,3-8H2,1-2H3

Upstream product

• 139605-61-1 4-formyl-piperazine-1-carboxylic acid diethylamide 
• 88-10-8 N,N-diethylcarbamyl chloride 
• 75529-71-4 N,N-diethyl-N'-(4-(phenylmethyl)piperazinyl)urea 

Downstream Products

• 90-89-1 diethylcarbamazine 
• 79352-77-5 4-(5-Amino-2-methoxy-benzyl)-piperazine-1-carboxylic acid diethylamide 
• 114259-90-4 4-[5-(7-Chloro-quinolin-4-ylamino)-2-hydroxy-benzoyl]-piperazine-1-carboxylic acid diethylamide 
• 114259-84-6 4-(5-Amino-2-hydroxy-benzoyl)-piperazine-1-carboxylic acid diethylamide 
• 79352-76-4 2-<<4-(diethylcarbamoyl)-1-piperazinyl>methyl>-4-nitroanisole 
• 114259-80-2 4-(2-Hydroxy-5-nitro-benzoyl)-piperazine-1-carboxylic acid diethylamide 
• 30146-59-9 4-(4-amino-6-morpholin-4-yl-[1,3,5]triazin-2-ylmethyl)-piperazine-1-carboxylic acid diethylamide 

Relevant academic research and scientific papers

Insertion of arynes into N-halo bonds: A direct approach to O -haloaminoarenes

A new approach to access o-haloaminoarenes has been achieved by insertion of arynes into a nitrogen-halide bond (N-X). This transition-metal-free transformation displays a broad substrate scope of arynes, good compatibility with functional groups, and high regioselectivity. Representative transformations of the o-haloaminoarenes are described to highlight their utility for rapid access to diversely functionalized aminoarene derivatives.

Synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors

A series of N1-activated C4-carboxy azetidinones was prepared and tested as inhibitors of human tryptase. The key stereochemical and functional features required for potency, serine protease specificity and aqueous stability were determined. From these studies compound 2, BMS-262084, was identified as a potent and selective tryptase inhibitor which, when dosed intratracheally in ovalbumin-sensitized guinea pigs, reduced allergen-induced bronchoconstriction and inflammatory cell infiltration into the lung.

Studies in Potential Filaricides: Part XV - Synthesis of 1-Acyl/Aryl-4-substituted-piperazines as Diethylcarbamazine Analogs

1-Acyl-4-substituted-piperazines (4-29) have been prepared starting from 1-benzylpiperazine while 1-aryl-4-aroylpiperazines (30-44) have been obtained from the corresponding 1-arylpiperazines.None of the compounds shows any significant filaricidal activity against Litomosoides carinii in cotton rats and cestodicial activity against Hymenolepis nana in mice.