119-96-0

Basic information

• Product Name: arsthinol
• Synonyms: arsthinol;Balarsen;Mercaptoarsenol;N-[2-Hydroxy-5-(4-hydroxymethyl-1,3,2-dithiarsolan-2-yl)phenyl]acetamide;N-[2-hydroxy-5-(4-methylol-1,3,2-dithiarsolan-2-yl)phenyl]acetamide;N-[2-hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl]ethanamide;N-(2-hydroxy-5-(4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl)phenyl)acetamide(WXG02283)
• CAS NO: 119-96-0
• Molecular Formula: C₁₁H₁₄AsNO₃S₂
• Molecular Weight: 0
• EINECS: 204-361-7
• Mol File: 119-96-0.mol
• Article Data: 1

Chemical Properties

• Melting Point: 163-166°
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: g/cm³
• CAS DataBase Reference: arsthinol(CAS DataBase Reference)
• NIST Chemistry Reference: arsthinol(119-96-0)
• EPA Substance Registry System: arsthinol(119-96-0)

Safety Data

• Hazardous Substances Data: 119-96-0(Hazardous Substances Data)

Usage

Originator

Arsthinol,ZYF Pharm Chemical

Uses

Pharmaceutic aid (vehicle, flavored); pharmaceutic F110aid (vehicle, sweetened).

Manufacturing Process

0.1 mol of 4-hydroxy-3-acetylaminophenyl-arsenoxide is suspended in 50 times its weight of water, and to the suspension 3 mols of sodium carbonate and 11 ml (110 mmols) of 2,3-dimercaptopropanol are added with rapid stirringfor 60 min. The resulting precipitate is filtered off, washed with water and dried in vacuo. So the N-[2-hydroxy-5-[4-(hydroxymethyl)-1,3,2-dithiarsolan-2-yl]phenyl] acetamide, melting point 163°-166°C is obtained.

Therapeutic Function

Antiprotozoal

InChI:InChI=1/C11H14AsNO3S2/c1-7(15)13-10-4-8(2-3-11(10)16)12-17-6-9(5-14)18-12/h2-4,9,14,16H,5-6H2,1H3,(H,13,15)

Upstream product

• 97-44-9 acetarsone 
• 59-52-9 2,3-dimercaptopropanol 

Related news

Pharmacokinetics and tissue distribution of the antileukaemic organoarsenicals arsthinol (cas 119-96-0) and melarsoprol in mice08/28/2019

Melarsoprol and arsthinol have been shown to be effective on various leukaemia cell lines. Nevertheless, the tissue distribution of these compounds remains a key point since the bone marrow is considered as the site of action and the central nervous system as the site of the main toxicity. In th...detailed

Relevant articles and documents

(2-Phenyl-[1,3,2]dithiarsolan-4-yl)-methanol derivatives show in vitro antileukemic activity

The antileukemic activity of a series of (2-Phenyl-[1,3,2]dithiarsolan-4- yl)-methanol derivatives was tested on K562 and U937 human leukemia cell lines. Their systemic toxicity was estimated by the corresponding LD50 on mice. The cytotoxic activity of each derivative was significantly better than that of arsenic trioxide and the therapeutic index (T.I. = LD 50/IC50) was improved. No correlation between log P and the activity or the toxicity was found.