119005-08-2

Upstream product

• 119005-05-9 (20S)-6β-methoxy-25-((2'-tetrahydropyranyl)oxy)-23,24-bisdehydro-3α,5α-cyclocholestan-21-ol 
• 98-59-9 p-toluenesulfonyl chloride 
• 119005-04-8 6β-methoxy-21,22-epoxy-3α,5α-cyclobisnorcholane 
• 119005-03-7 6β-methoxy-3α,5α-cyclobisnorcholane-21,22-diol 
• 126640-58-2 4-((3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-2,2-dimethyl-[1,2]oxasilolane 
• 74348-77-9 ethyl 6β-methoxy-3α,5α-cyclopregnan-21-oate 
• 119068-30-3 (Z)-6β-methoxy-3α,5α-cyclopregn-17(20)en-21-ol 
• 87726-19-0 ethyl (Z)-6β-methoxy-3α,5α-cyclopregn-17(20)-en-21-oate 
• 64338-43-8 [(3aR,3bS,5aS,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-tetradecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-(6E)-ylidene]-acetic acid ethyl ester 
• 119005-07-1 (Z)-21-(((bromomethyl)dimethylsilyl)oxy)-6β-methoxy-3α,5α-cyclopregn-17(20)-ene 
• 96354-27-7 lithium acetylide of 2-methyl-3-butyn-2-ol 
• 119005-02-6 (S)-((3aR,3bS,5aS,6S,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-phenylselanyl-acetic acid ethyl ester 
• 132101-64-5 3-methyl-3-(tetrahydro-2H-pyran-2-yloxy)butyne 
• 119005-00-4 (E)-6β-methoxy-3α,5α-cyclopregn-17(20)en-21-ol 

Downstream Products

• 2140-46-7 20(S) 25-hydroxycholesterol 

Relevant academic research and scientific papers

Methylation and Hydroxymethylation of Allylic Alcohols via Radical Cyclization. Methodology for Stereoselective Construction of an Aliphatic Chain in Application to Sterol Synthesis

Reductive free-radical cyclization of (bromomethyl)dimethylsilyl derivatives (6b-9b) of allylic alcohols (6a-9a) was studied to evaluate the scope of a novel method of methylation and hydroxymethylation of allylic alcohols.Treatment of (bromomethyl)dimeth

METHYLATION AND HYDROXYMETHYLATION INVOLVING FREE RADICALS. AN APPLICATION TO STEREOSELECTIVE CONSTRUCTION OF 20(S) STEROL SIDE-CHAIN

Reductive radical cyclization of bromomethyl-silyl-ethers 1b and 2b was found to proceed in 5-exo-mode.Epimeric cyclic siloxanes 3 were transformed stereoselectively into 20(S) 25-hydroxycholesterol.Unsaturated (E) ester 4 was converted to its (Z) isomer 7 via saturation and selective dehydrogenation.