1190060-36-6

Basic information

• Product Name: 4-(3-oxo-1-propyn-1-yl)benzonitrile
• Synonyms: 4-(3-oxo-1-propyn-1-yl)benzonitrile
• CAS NO: 1190060-36-6
• Molecular Weight: 155.156
• Mol File: 1190060-36-6.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 4-(3-oxo-1-propyn-1-yl)benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-oxo-1-propyn-1-yl)benzonitrile(1190060-36-6)
• EPA Substance Registry System: 4-(3-oxo-1-propyn-1-yl)benzonitrile(1190060-36-6)

Safety Data

• Hazardous Substances Data: 1190060-36-6(Hazardous Substances Data)

Upstream product

• 3058-39-7 4-iodobenzonitrile 
• 107-19-7 propargyl alcohol 
• 143952-58-3 ethyl 3-(4-cyanophenyl)propynoate 
• 80151-16-2 3-(4-cyanophenyl)-2-propyne-1-ol 
• 3032-92-6 4-cyanophenylacetylene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 1190060-39-9 4-(5-formyl-2H-1,2,3-triazol-4-yl)benzonitrile 
• 1301185-56-7 C₁₁H₆N₂O 
• 1416700-21-4 C₂₃H₁₆N₂O₃ 
• 1399086-01-1 4-(3-formylquinolin-2-yl)benzonitrile 
• 1399086-23-7 (R)-(E)-4-(4-(4-bromostyryl)-3-formyl-4-hydroxy-1-(trifluoromethylsulfonyl)-1,4-dihydroquinolin-2-yl)benzonitrile 
• 1399086-25-9 (R)-(E)-4-(3-formyl-4-hydroxy-4-(3-methoxystyryl)-1-(trifluoromethylsulfonyl)-1,4-dihydroquinolin-2-yl)benzonitrile 

Relevant articles and documents

Transition-metal-free and facile synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde

A transition-metal-free, facile and efficient method for the synthesis of 3-alkynylpyrrole-2,4-dicarboxylates from methylene isocyanides and propiolaldehyde with moderate to good yields has been developed. The direct transformation process and good tolerance of various substituents make it an alternative approach to previous protocols, and potential applications of these investigated compounds are expected with or without post-modifications.

Gold-Catalyzed Synthesis of 2,5-Disubstituted Oxazoles from Carboxamides and Propynals

2,5-Disubstituted oxazoles are synthesized by oxidative gold catalysis. In contrast to a reported procedure that delivers 2,4-disubstituted oxazoles starting from terminal alkynes, a switch in selectivity towards a 2,5-disubstitution is achieved by the use of propynals as starting materials. In the new reaction, the key intermediate is formed by the nucleophilic attack of the carboxamide onto a gold carbenoid, and then condensates with the more electrophilic aldehyde moiety already present in the substrate and not with the ketone that is derived from the oxygen donor. This new cyclization mode introduces a new carbonyl moiety as substituent at the 2,5-disubstituted oxazole, an attractive motive that can be found in bioactive compounds or be used for further derivatizations. (Figure presented.).

ARGININE METHYLTRANSFERASE INHIBITORS AND USES THEREOF

Described herein are compounds of Formula (I), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting arginine methyltransferase activity. Methods of using the compo