1190071-45-4Relevant academic research and scientific papers
Enantioselective, organocatalytic reduction of ketones using bifunctional thiourea-amine catalysts
Li, De Run,He, Anyu,Falck
, p. 1756 - 1759 (2010)
Prochiral ketones are reduced to enantioenriched, secondary alcohols using catecholborane and a family of air-stable, bifunctional thiourea-amine organocatalysts. Asymmetric induction is proposed to arise from the in situ complexation between the borane and chiral thiourea-amine organocatalyst resulting in a stereochemically biased boronate-amine complex. The hydride in the complex is endowed with enhanced nucleophilicity while the thiourea concomitantly embraces and activates the carbonyl.
Chiral thiourea compounds and process for enantioselective reduction of ketones
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Page/Page column 7, (2009/10/18)
Chiral thioureas are effective catalysts for the borane reduction of prochiral ketones to optically active alcohols. A prochiral ketone may be reduced to an optically active alcohol in the presence of a substantially sub-stoichiometric amount of chiral thiourea. The asymmetric thiourea compound of the present invention may be produced according to a production method described herein.
