1190094-64-4

Basic information

• Product Name: OSI-754
• Synonyms: OSI-754;CP 609754;LNK 754;CP-609754 (OSI754);6-[(R)-(4-chlorophenyl)-hydroxy-(3-methylimidazol-4-yl)methyl]-4-(3-ethynylphenyl)-1-methylquinolin-2-one
• CAS NO: 1190094-64-4
• Molecular Formula: C29H22ClN3O2
• Molecular Weight: 479.95688
• Mol File: 1190094-64-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 702.4±60.0 °C(Predicted)
• Appearance: /
• Density: 1.23±0.1 g/cm3(Predicted)
• PKA: 12.28±0.29(Predicted)
• CAS DataBase Reference: OSI-754(CAS DataBase Reference)
• NIST Chemistry Reference: OSI-754(1190094-64-4)
• EPA Substance Registry System: OSI-754(1190094-64-4)

Safety Data

• Hazardous Substances Data: 1190094-64-4(Hazardous Substances Data)

Usage

General Description

OSI-754 is a potent inhibitor of the insulin-like growth factor-I receptor (IGF-IR) and insulin receptor. It has been shown to exhibit antitumor activity in various preclinical cancer models, potentially by suppressing tumor cell growth and inducing apoptosis. OSI-754 has also been reported to block the downstream signaling of IGF-IR, leading to a decrease in phosphorylation of Akt and Erk, which are involved in cell survival and proliferation. OSI-754 has shown promising therapeutic potential in the treatment of several types of cancer and has been the subject of ongoing research and clinical trials.