1190129-65-7Relevant academic research and scientific papers
The enantioselective benzoin condensation promoted by chiral triazolium precatalysts: Stereochemical control via hydrogen bonding
O'Toole, Sarah E.,Connon, Stephen J.
supporting information; experimental part, p. 3584 - 3593 (2010/01/06)
The design of a new class of triazolium ion precatalysts incorporating protic substituents is described. These materials promote the enantioselective benzoin condensation of a range of aromatic aldehydes (1-62% ee). Catalyst evaluation studies strongly support the involvement of hydrogen bond donation by the catalyst in the stereocentre-forming step of the catalytic cycle.
