119016-74-9Relevant academic research and scientific papers
Synthesis, characterization, cytotoxicity, and molecular docking studies of ampyrone-based transition metal complexes
Azam, Mohammad,Wabaidur, Saikh Mohammad,Alam, Mahboob,Khan, Zahid,Alanazi, Ibrahim O.,Al-Resayes, Saud I.,Moon, Il Soo,Rajendra
, p. 65 - 71 (2021)
A novel series of mononuclear transition metal complexes, [Cu(L)Cl] 1, [Zn(L)Cl] 2, [Pd(L)Cl] 3, [Cd(L)I] 4, [Pt(L)Cl] 5, and [Hg(L)Cl] 6, was constructed from a pyrazole-derived Schiff ligand, HL, and characterized by physicochemical and spectroscopic methods. Fourier-transform infrared (FT-IR) spectral data showed the studied ligand to be tridentate and coordinated to the metal ions via ONO donor atoms, whereas powder X-ray diffraction (PXRD) analysis revealed the crystalline nature of all the complexes. The in vitro cytotoxicity of the studied ligand and its complexes were tested by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium (MTS) assay against the human colorectal cancer cell lines HCT116 and HT29. The results suggested that the HCT116 cell line is highly sensitive to complex 1 with a half-maximal inhibitory concentration (IC50) of 45.6?μM, while both cell lines tolerated complexes 2 and 4 better in comparison with HL. In addition, complex 1 with significant anticancer activity was analyzed by molecular docking studies to explore its binding efficacy to the cyclin-dependent kinase?2 active site.
