119020-75-6

Upstream product

• 15988-11-1 4-Phenylurazole 
• 6832-16-2 methyl diazoacetate 
• 2693-32-5 2-diphenylmethyliumyl-3,5-dioxo-4-phenyl-1,2,4-triazolidin-1-ide 
• 4233-33-4 4-Phenyl-1,2,4-triazolidine-3,5-dione 

Relevant academic research and scientific papers

Method for control of hyperlipidemia

The present invention is directed to a method of controlling hyperlipidemia in mammals which comprises administering to a mammal an amount effective to control hyperlipidemia of a compound having hypolipidemic activity and the structural formula: STR1 wherein R1 is hydrogen, a C1 to C18 alkyl or substituted alkyl, a C2 to C18 alkenyl or substituted alkenyl, a C2 to C18 alkynyl or substituted alkynyl, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, phenyl, a substituted phenyl, cyano, phenalkyl, --CO--R9 or --Y--CO--R9 ; R2 is STR2 R3 and R4 can be the same or different and are each the same as R1 ; R5, R6 and R7 can be the same or different and are each hydrogen, a C1 to C18 alkyl or substituted alkyl, a C2 to C18 alkenyl or substituted alkenyl, a C1 to C18 alkynyl or substituted alkynyl, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, phenyl or substituted phenyl, phenalkyl, --CO--R9, or --Y--CO--R9, with the proviso that R5 and R6 together cannot be so bulky as to cause the compound to decompose; R8 is hydrogen, a C1 to C5 alkyl, a C4 to C10 cycloalkyl, --CO--R9 or Y--CO--R9 ; R9 is hydrogen, a C1 to C5 alkyl or substituted alkyl, a C2 to C5 alkenyl or substituted alkenyl, a C2 to C5 alkynyl or substituted alkynyl, phenyl or substituted phenyl, phenoxy or substituted phenoxy, a C1 to C5 alkoxy or substituted alkoxy, a C4 to C10 cycloalkyl or substituted cycloalkyl, a C4 to C10 cycloalkenyl or substituted cycloalkenyl, --NHC6 C5l , --NR10 R11 wherein R10 and R11 can be the same or different and are each hydrogen, a C1 to C5 alkyl or substituted alkyl, phenyl or substituted phenyl; Y is a C1 to C10 alkylene or substituted alkylene; R12 is --CO, --COH, --CS, --CSH, or a C1 to C4 alkylene group; and and the pharmaceutically acceptable salts, and mixtures thereof.

Reaction of Diazoalkanes with 4-Substituted 1,2,4-Triazole-3,5(4H)-diones

Diazoacetic esters reacted with 4-substituted 1,2,4-triazole-3,5(4H)-diones (2) to give one-to-one adducts.Molecular weight determination, high-performance-liquid chromatography, and 2D n.m.r. spectroscopy showed that the adducts are monomers that associate in solution.The monomers are most likely 1,3,5-triazabicyclohexane-2,4-diones.The adducts were thermally isomerized to 3,6-disubstituted 1,3,5-triazine-2,4(1H,3H)-diones.Diphenyldiazomethane reacted with (2) to yield an azomethine imine, which underwent thermal dimerization followed by rearrangement.