1190207-33-0Relevant academic research and scientific papers
Steric influence of N-phosphorus-arylimines on the rhodium-catalyzed asymmetric arylation
Hao, Xinyu,Chen, Qian,Yamada, Ken-Ichi,Yamamoto, Yasutomo,Tomioka, Kiyoshi
experimental part, p. 6469 - 6473 (2011/09/20)
Examination of the rhodium-catalyzed asymmetric arylation of benzaldehyde-imines bearing ethoxy, isopropoxy, phenyl, cyclohexyl, 3,5-xylyl, and 2,4,6-mesityl N-phosphorus activating/protecting groups revealed that bulky N-phosphorus groups retarded the arylation and at the same time prevented the competitive hydrolysis of an imine. Although the level of enantioselectivity was dependent favorably on the bulkiness ranging from 88% ee to 53% ee, the reactivity was drastically decreased along with bulkiness ranging from 95% to 3%.
Steric tuning of the amidomonophosphane-rhodium(l) catalyst in asymmetric addition of arylboroxines to n-phosphinoyl aldimines
Hao, Xinyu,Kuriyama, Masami,Chen, Qian,Yamamoto, Yasutomo,Yamada, Ken-Ichi,Tomioka, Kiyoshi
supporting information; experimental part, p. 4470 - 4473 (2009/12/24)
Highly enantioselective rhodium-catalyzed addition of arylboroxlnes to N-phosphinoylaldimines was realized by the steric tuning of a dlphenylphosphorus moiety to a di(o-tolyl)phosphorus moiety of a chiral amidomonophosphane. The presence of MS 4 A in a 5:1 solvent mixture of dioxane-propanol was essential to afford the corresponding dlarylmethylamines In high yield.
