1190306-44-5Relevant academic research and scientific papers
MACROCYCLIC PYRIMIDINE DERIVATIVES
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Page/Page column 89, (2009/10/17)
Macrocyclic pyrimidine compounds, compositions comprising such compounds, methods for making the compounds, and methods of treating and preventing the progression of diseases, conditions, and disorders using such compounds and compositions are described h
Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: A new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models
Cowart, Marlon D.,Altenbach, Robert J.,Liu, Huaqing,Hsieh, Gin C.,Drizin, Irene,Milicic, Ivan,Miller, Thomas R.,Witte, David G.,Wishart, Neil,Fix-Stenzel, Shannon R.,McPherson, Michael J.,Adair, Ronald M.,Wetter, Jill M.,Bettencourt, Brian M.,Marsh, Kennan C.,Sullivan, James P.,Honore, Prisca,Esbenshade, Timothy A.,Brioni, Jorge D.
experimental part, p. 6547 - 6557 (2009/10/09)
A new structural class of histamine H4 receptor antagonists (6-14) was designed based on rotationally restricted 2,4-diaminopyrimidines. Series compounds showed potent and selective in vitro H4 antagonism across multiple species, goo
