1190318-91-2 Usage
Structure
An azaindole derivative with:
A cyano group ( -\textCN ) attached to the 6th position.
An iodine atom ( \textI ) attached to the 3rd position.
Applications
Organic Synthesis: Utilized as a building block for the synthesis of various organic compounds due to its versatile reactivity.
Medicinal Chemistry: Potential applications in drug discovery and development, owing to its pharmacophore properties.
Material Science: Used in the development of novel materials due to its unique structural features.
Value as a Building Block
Pharmaceuticals: Serves as a precursor in the synthesis of pharmaceuticals and drug candidates.
Agrochemicals: Used in the synthesis of agrochemicals, contributing to the development of pesticides and herbicides.
Interest in Research and Industry
Scientific Advancement: Holds promise for contributing to advancements in various scientific fields.
Technological Innovation: Potential to drive innovation in chemical processes and material development.
Significance
Unique Structure: Its distinct molecular structure makes it valuable for diverse applications.
Versatile Reactivity: Exhibits a wide range of reactivity, enhancing its utility in chemical synthesis.
Potential Impact: Considered a compound of interest for its potential contributions to science and technology.
Check Digit Verification of cas no
The CAS Registry Mumber 1190318-91-2 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,9,0,3,1 and 8 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1190318-91:
(9*1)+(8*1)+(7*9)+(6*0)+(5*3)+(4*1)+(3*8)+(2*9)+(1*1)=142
142 % 10 = 2
So 1190318-91-2 is a valid CAS Registry Number.
1190318-91-2Relevant articles and documents
An orally available, brain-penetrant CAMKK2 inhibitor reduces food intake in rodent model
Price, Daniel J.,Drewry, David H.,Schaller, Lee T.,Thompson, Brian D.,Reid, Paul R.,Maloney, Patrick R.,Liang, Xi,Banker, Periette,Buckholz, Richard G.,Selley, Paula K.,McDonald, Octerloney B.,Smith, Jeffery L.,Shearer, Todd W.,Cox, Richard F.,Williams, Shawn P.,Reid, Robert A.,Tacconi, Stefano,Faggioni, Federico,Piubelli, Chiara,Sartori, Ilaria,Tessari, Michela,Wang, Tony Y.
, p. 1958 - 1963 (2018)
Hypothalamic CAMKK2 represents a potential mechanism for chemically affecting satiety and promoting weight loss in clinically obese patients. Single-digit nanomolar inhibitors of CAMKK2 were identified in three related ATP-competitive series. Limited optimization of kinase selectivity, solubility, and pharmacokinetic properties were undertaken on all three series, as SAR was often transferrable. Ultimately, a 2,4-diaryl 7-azaindole was optimized to afford a tool molecule that potently inhibits AMPK phosphorylation in a hypothalamus-derived cell line, is orally bioavailable, and crosses the blood–brain barrier. When dosed orally in rodents, compound 4 t limited ghrelin-induced food intake.
