1190319-62-0

Basic information

• Product Name: 6-Bromo-4-aza-2-oxindole
• Synonyms: 6-Bromo-4-aza-2-oxindole;6-bromo-1H-pyrrolo[3,2-b]pyridin-2(3H)-one;6-broMo-1H,2H,3H-pyrrolo[3,2-b]pyridin-2-one;3-bromo-6,7-dihydropyrrolo[3,4-b]pyridin-5-one
• CAS NO: 1190319-62-0
• Molecular Formula: C₇H₅BrN₂O
• Molecular Weight: 213.0314
• EINECS: 200-258-5
• Mol File: 1190319-62-0.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 345.675 °C at 760 mmHg
• Flash Point: 162.858 °C
• Appearance: /
• Density: 1.768 g/cm³
• PKA: 12.03±0.20(Predicted)
• CAS DataBase Reference: 6-Bromo-4-aza-2-oxindole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-4-aza-2-oxindole(1190319-62-0)
• EPA Substance Registry System: 6-Bromo-4-aza-2-oxindole(1190319-62-0)

Safety Data

• Hazardous Substances Data: 1190319-62-0(Hazardous Substances Data)

Usage

General Description

6-Bromo-4-aza-2-oxindole is an organic compound falling under the indoles group of chemical substances. Known for its bromination feature, it plays a significant role in organic synthesis and medicinal chemistry. This chemical is typically used in research and pharmaceutical sectors for the development of novel therapeutic agents or drugs. It holds importance due to its possible connections in a variety of bioactivities. However, specific details of its properties and related applications may still require further research and investigation in the field of organic chemistry.

Upstream product

• 1379312-86-3 ethyl 2-(3-Amino-5-bromopyridin-2-yl)acetate 
• 1211540-74-7 ethyl 2-(5 -bromo-3-nitropyridin-2-yl)acetate 
• 911434-04-3 2-(5-bromo-3-nitro-pyridin-2-yl)-malonic acid diethyl ester 
• 67443-38-3 5-bromo-2-chloro-3-nitropyridine 
• 1190862-16-8 dibenzyl 2-(5-bromo-3-nitropyridin-2-yl)malonate 

Downstream Products

• 1360822-14-5 Z-6-bromo-3-(3-chloro-2-fluorobenzylidene)-1,3-dihydropyrrolo[3,2-b]pyridin-2-one 
• 1190886-60-2 C₂₃H₂₃F₂N₃O₂ 
• 1190860-44-6 N-cyclopropyl-4-methyl-3-(2'-oxo-1',2,2',3,5,6-hexahydrospiro[pyran-4,3'-pyrrolo-[3,2-b]pyridin]-6'-yl)benzamide 

Relevant articles and documents

1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one derivative and medical application thereof

The invention discloses a 1,3-dihydro-2H-pyrrolo[3,2-b]pyridin-2-one derivative and medical application thereof. A compound is a compound shown in a formula I, or a pharmaceutically acceptable salt ora stereoisomer or a tautomer thereof, wherein R1-R4 is defined by the specification.

NOVEL SUBSTITUTED PYRIMIDINE COMPOUNDS

The invention relates to novel substituted pyrimidine compounds of general formula (I), in which the chemical groupings, substituents, variables and indices are as defined in the description, and to their use as medicaments, in particular as medicaments for the treatment of conditions and diseases that can be treated by inhibition of the PDE4 enzyme.

Indolin-2-one p38α inhibitors II: Lead optimisation

Optimisation of a series of indolin-2-one p38α inhibitors was achieved via both blocking of a potential metabolic 'hot spot' and by increasing overall polarity of the lead series leading to non-cytotoxic compounds which showed improved oral bioavailabilities in the rat.