119033-83-9

Usage

Uses

Used in Pharmaceutical Industry:
(2E)-N-(4-chlorophenyl)-2-(furan-2-ylmethylidene)hydrazinecarbothioamide is used as a pharmaceutical compound for its potential biological activities. Its antimicrobial, antifungal, and anticancer properties make it a promising candidate for the development of new drugs and therapies.
Used in Antimicrobial Applications:
(2E)-N-(4-chlorophenyl)-2-(furan-2-ylmethylidene)hydrazinecarbothioamide is used as an antimicrobial agent to combat various types of bacteria and inhibit their growth.
Used in Antifungal Applications:
(2E)-N-(4-chlorophenyl)-2-(furan-2-ylmethylidene)hydrazinecarbothioamide is used as an antifungal agent to treat fungal infections and prevent the growth of fungi.
Used in Anticancer Applications:
(2E)-N-(4-chlorophenyl)-2-(furan-2-ylmethylidene)hydrazinecarbothioamide is used as an anticancer agent to target and inhibit the growth of cancer cells, making it a potential candidate for cancer treatment and therapy development.

Upstream product

• 106-47-8 4-chloro-aniline 
• 26152-23-8 furfurylidene-hydrazinecarbodithioic acid methyl ester 
• 98-01-1 furfural 
• 22814-92-2 4-(p-chlorophenyl)-3-thiosemicarbazide 
• 2131-55-7 4-Chlorophenyl isothiocyanate 

Relevant academic research and scientific papers

Synthesis and fungicidal activities of some 2-substituted arylamino-5-(2′-furyl)-1,3,4-thiadiazolo[3,2-c]thiazoles and 5-substituted aryl-2-substituted arylamino-1,3,4-thiadiazolo[3,2-c]thiazoles

Several 2-substituted arylamino-5-(2′-furyl)-1,3,4-thiadiazolo[3,2-c] thiazoles have been synthesised by cyclisation of 3-substituted aryl thiocarbanilido-2-(2′-furyl)thiazolidin-4-ones with cone. H 2SO4 with constant stirring in cold and 5-substituted aryl-2-substituted arylamino-1,3,4-thiadiazolo[3,2-c]thiazoles have been synthesised by the cyclisation of 2-substituted aryl-3-substituted arylthiourido-thiazolidin-4-ones with cone. H2SO4 with constant stirring in cold and screened for their antifungal activities against Helminthosporium oryzae and Cephalosporium sacchari.

Synthesis and Ribonucleotide reductase inhibitory activity of thiosemicarbazones

Ribonucleotide reductase (RR) is an important therapeutic target for anticancer drugs. The structure of human RR features a 1:1 complex of two homodimeric subunits, hRRM1 and hRRM2. Prokaryotically expressed and highly purified recombinant human RR subunits, hRRM1 and hRRM2, were used for holoenzyme-based [3H]CDP reduction in vitro assay. Ten new thiosemicarbazones (7-16) were synthesized and screened for their RR inhibitory activity. Two thiosemicarbazones derived from p-hydroxy benzaldehyde (9 and 10) were found to be active but less potent than the standard, Hydroxyurea (HU). Guided by the activity of compounds 9 and 10, 11 new thiosemicarbazones (17-27) derived from p-hydroxy benzaldehyde were prepared and screened for their RR inhibitory activity. All the 11 compounds were more potent than HU.