1190373-69-3Relevant academic research and scientific papers
Synthesis and cytotoxicity of novel chrysin derivatives
Hu, Kun,Wang, Wei,Cheng, Hong,Pan, ShaSha,Ren, Jie
experimental part, p. 838 - 846 (2012/05/04)
A series of chrysin derivatives 8a-8v were prepared and tested in vitro against HCT-116 (human colon cancer cell line), Hela (human cervical carcinoma cell line), DU-145 (human prostate cell line), K562 (human leukemia cell line), and SGC-7901 (human gastric cancer cell line). The chemical structures of these compounds were confirmed by means of MS, IR, 1H NMR, 13C NMR, and elemental analysis. Among these derivatives, 7-(2-(piperazin-1- yl)ethoxy)-5-hydroxy-2-phenyl-4H-chromen-4-one, 8n, had the strongest activity against HCT-116, Hela, DU-145, K562, and SGC-7901 cells. Springer Science+Business Media, LLC 2010.
Synthesis of C(7) modified chrysin derivatives designing to inhibit β-ketoacyl-acyl carrier protein synthase III (FabH) as antibiotics
Li, Huan-Qiu,Shi, Lei,Li, Qing-Shan,Liu, Peng-Gang,Luo, Yin,Zhao, Jing,Zhu, Hai-Liang
experimental part, p. 6264 - 6269 (2011/02/24)
As a naturally wide distributed flavone, chrysin exhibits numerous biological activities including anticancer, anti-inflammatory, and antimicrobials activities. β-Ketoacyl-acyl carrier protein synthase III (FabH) catalyzes the initial step of fatty acid b
