1190439-39-4

Basic information

• Product Name: 3-(2'-methoxy)phenyl-6-methylcoumarin
• Synonyms: 3-(2'-methoxy)phenyl-6-methylcoumarin
• CAS NO: 1190439-39-4
• Molecular Weight: 266.296
• Mol File: 1190439-39-4.mol

Chemical Properties

• CAS DataBase Reference: 3-(2'-methoxy)phenyl-6-methylcoumarin(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2'-methoxy)phenyl-6-methylcoumarin(1190439-39-4)
• EPA Substance Registry System: 3-(2'-methoxy)phenyl-6-methylcoumarin(1190439-39-4)

Safety Data

• Hazardous Substances Data: 1190439-39-4(Hazardous Substances Data)

Upstream product

• 613-84-3 2-hydroxy-5-methylbenzaldehyde 
• 93-25-4 2-methoxyphenylacetic acid 

Downstream Products

• 1338596-79-4 3-(2-hydroxyphenyl)-6-methyl-2H-chromen-2-one 

Relevant articles and documents

Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors

A series of 6-methyl-3-phenylcoumarins 3-6 were synthesized and evaluated as monoamine oxidase A and B (MAO-A and MAO-B) inhibitors. A comparative study between the three possible mono methoxy 3-phenyl derivatives and the p-hydroxy analogue is reported. T

Comparative study of the 3-phenylcoumarin scaffold: Synthesis, X-ray structural analysis and semiempirical calculations of a selected series of compounds

Compounds 1 (6-methyl-3-phenylcoumarin), 2 (3-(o-methoxyphenyl)-6- methylcoumarin) and 3 (3-(m-methoxyphenyl)-6-methylcoumarin) were synthesized by a Perkin reaction between the 2-hydroxy-5-methylbenzaldehyde and the corresponding phenyl acetic acid. sup

Remarkable antioxidant properties of a series of hydroxy-3-arylcoumarins

In the present work we synthesized a series of hydroxy-3-arylcoumarins (compounds 1-9), some of them previously described as MAO-B selective inhibitors, with the aim of evaluating their antioxidant properties. Theoretical evaluation of ADME properties of all the derivatives was also carried out. From the ORAC-FL, ESR and CV data it was concluded that these derivatives are very good antioxidants, with a very interesting hydroxyl, DPPH and superoxide radicals scavenging profiles. In particular compound 9 is the most active and effective antioxidant of the series (ORAC-FL = 13.5, capacity of scavenging hydroxyl radicals = 100%, capacity of scavenging DPPH radicals = 65.9% and capacity of scavenging superoxide radicals = 71.5%). Kinetics profile for protection fluorescein probe against peroxyl radicals by addition of antioxidant molecule 9 was also performed. Therefore, it can operate as a potential candidate for preventing or minimizing the free radicals overproduction in oxidative-stress related diseases.

Synthesis and study of a series of 3-arylcoumarins as potent and selective monoamine oxidase B inhibitors

New series of 6-substituted-3-arylcoumarins displaying several alkyl, hydroxyl, halogen, and alkoxy groups in the two benzene rings have been designed, synthesized, and evaluated in vitro as human monoamine oxidase A and B (hMAO-A and hMAO-B) inhibitors.