1190441-59-8Relevant academic research and scientific papers
Sequential Intermolecular Radical Addition and Reductive Radical Cyclization of Tyrosine and Phenylalanine Derivatives with Alkenes via Photoinduced Decarboxylation: Access to Ring-Constrained γ-Amino Acids
Osaka, Kazuyuki,Usami, Ayuka,Iwasaki, Tomoya,Yamawaki, Mugen,Morita, Toshio,Yoshimi, Yasuharu
, p. 9480 - 9488 (2019)
Sequential radical addition to alkenes and reductive radical cyclization of phenylalanine and tyrosine derivatives via photoinduced decarboxylation furnished ring-constrained γ-amino acids under mild conditions. A variety of alkenes such as acrylamides and acrylic esters could be employed in the photoinduced radical cascade cyclization. The yields of the ring-constrained γ-amino acids are dependent on the electron-accepting ability and steric hindrance of the alkene used. The proposed sequential reaction can also be applied for direct tethering of dipeptides to yield unique ring-constrained tetrapeptides.
Inter- and intramolecular addition reactions of electron-deficient alkenes with alkyl radicals, generated by SET-photochemical decarboxylation of carboxylic acids, serve as a mild and efficient method for the preparation of γ-amino acids and macrocyclic l
Yoshimi, Yasuharu,Masuda, Miho,Mizunashi, Tomoyuki,Nishikawa, Keisuke,Maeda, Kousuke,Koshida, Nobumasa,Itou, Tatsuya,Morita, Toshio,Hatanaka, Minoru
supporting information; experimental part, p. 4652 - 4655 (2009/12/24)
Inter- and Intramolecular additions of alkyl radicals, generated by SET photochemical decarboxylation reactions of free carboxylic acids, to electron-deficient alkenes take place under mild conditions as part of efficient routes for the formation of NBoc
